姜黄素调控肠道菌群及其代谢物提高小鼠运动表现的研究  

Curcumin modulates gut microbiota and its metabolites to improve exercise performance in mice

作　　者：颜惠敏 吕欣晨 宋雯燕 陆文伟[1] 王鸿超[1] YAN Huimin;LYU Xinchen;SONG Wenyan;LU Wenwei;WANG Hongchao(School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学食品学院,江苏无锡214122

出　　处：《食品与发酵工业》2025年第8期37-44,共8页Food and Fermentation Industries

基　　金：国家重点研发计划项目(2022YFF1100403)。

摘　　要：姜黄素是一种天然多酚类化合物,具备多重生理活性且有提高运动表现的功效。该研究对雄性ICR小鼠进行6周姜黄素干预以及2周的游泳训练,旨在探究姜黄素对小鼠运动表现的影响及其潜在机制。结果表明,姜黄素显著提高了小鼠的运动耐力以及抗疲劳能力,并且改善了小鼠血清和肌肉代谢,增加了糖原储备。此外,姜黄素还能改善肠道菌群,提高肠道内短链脂肪酸和脂肪酸酰胺含量。相关性分析表明,Bacteroides xylanisolvens和Parabacteroides goldsteinii的相对丰度以及肠道内短链脂肪酸和脂肪酸酰胺含量与小鼠运动表现显著正相关。综上所述,该研究揭示了姜黄素可能通过改善血清肌肉代谢、提高糖原储备、调节肠道菌群及其代谢产物等途径,提高小鼠的运动表现。Curcumin,a natural polyphenolic compound,exhibits multiple physiological activities and potential improvements in exercise performance.This study aimed to explore the effects of curcumin on exercise performance in male ICR mice following six weeks of curcumin intervention and two weeks of swimming training.Results showed that curcumin significantly enhanced mice endurance and anti-fatigue capacity,improved serum and muscle metabolism,and increased glycogen reserves.Additionally,curcumin intervention improved gut microbiota,elevating levels of short-chain fatty acids and fatty acid amides in the intestines.Correlation analysis revealed a positive association between the relative abundance of Bacteroides xylanisolvens and Parabacteroides goldsteinii with mouse exercise performance.Overall,this study elucidates curcumin’s potential mechanisms in enhancing exercise performance through metabolic improvements,glycogen storage enhancement,and modulation of gut microbiota and associated metabolites.

关 键 词：姜黄素 运动表现 肠道菌群 肠道菌群代谢物 

分 类 号：TS201.4[轻工技术与工程—食品科学]