大鲵骨肽缓解小鼠高尿酸作用研究  

Effect of bone peptide of giant salamander on alleviating hyperuric acid in mice

作　　者：郑小莉 陈德经[1,2] 苏文[1,2] 江海[1,2] 曾允灏 祁珊珊[1,2] ZHENG Xiaoli;CHEN Dejing;SU Wen;JIANG Hai;ZENG Yunhao;QI Shanshan(School of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723001,China;Shaanxi Provincial Key Laboratory of Resource Biology,Shaanxi University of Technology,Hanzhong 723001,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723001 [2]陕西理工大学陕西省资源生物重点实验室,陕西汉中723001

出　　处：《食品与发酵工业》2025年第8期267-275,共9页Food and Fermentation Industries

基　　金：陕西理工大学“市校共建”科研专项(SXZC202101)。

摘　　要：该研究以氧嗪酸钾诱导的高尿酸血症小鼠模型为对象,来评价不同剂量大鲵骨肽(Andrias davidianus bone peptides,ADBP)[150 mg/(kg·bw)、300 mg/(kg·bw)和600 mg/(kg·bw)]降尿酸功效。结果表明,ADBP可显著降低血清中尿酸(uric acid,UA)、肌酐和尿素氮水平,有效抑制UA合成相关酶,黄嘌呤氧化酶(xanthine oxidas,XOD)和腺苷脱氨酶的活力,下调高尿酸血症小鼠肝脏中XOD的mRNA表达水平。ADBP通过调节氧化应激(总抗氧化能力、超氧化物歧化酶、谷胱甘肽过氧化物酶、丙二醛含量),抑制促炎细胞因子(CXCL1、IL-1β、IL-6、TNF-α)水平,改善了肝脏和肾脏的组织病理学损伤。研究证实ADBP对高尿酸血症小鼠有明显的降尿酸作用,对长期高尿酸引起的机体损伤有一定的修复作用,可作缓解和治疗高尿酸血症的物质。In this study,the uric acid-lowering effects of Andrias davidianus bone peptides(ADBP)at different doses were evaluated in a mouse model of hyperuricemia induced by potassium oxonate,including 150 mg/(kg·bw),300 mg/(kg·bw),and 600 mg/(kg·bw).Results revealed that ADBP significantly reduced the levels of uric acid(UA),creatinine(CRE),and blood urea nitrogen(BUN)in serum,and effectively suppressed the activities of xanthine oxidase(XOD)associated with UA synthesis.Furthermore,it down-regulated the expression level of XOD mRNA in the liver of hyperuricemia mice.ADBP regulated oxidative stress(total antioxidant,superoxide dismutase,glutathione peroxidase,and malondialdehyde)and inhibited pro-inflammatory cytokines(CXCL1,IL-1β,IL-6,and TNF-α),resulting in improved histopathological damage in the liver and kidneys.Studies have confirmed that ADBP had a significant uric acid-lowering effect on hyperuricemia mice and could repair long-term damage caused by high uric acid.Therefore,it can be used to relieve and treat hyperuricemia.

关 键 词：大鲵骨肽 黄嘌呤氧化酶 高尿酸血症 氧化应激 炎症因子 

分 类 号：R285.5[医药卫生—中药学] TS254.1[医药卫生—中医学]