天然多肽的电化学修饰  

Electrochemical Modifications of Native Peptides

作　　者：林子涵 林婉真 陈发杰 Zihan Lin;Wanzhen Lin;Fa-Jie Chen(College of Chemistry,Fuzhou University,Fuzhou 305108,China;College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福州大学化学学院,福州305108 [2]福建中医药大学药学院,福州350122

出　　处：《大学化学》2025年第3期318-327,共10页University Chemistry

基　　金：福州大学本科生科研训练计划项目(30288);福州大学科研启动经费(511264);福建中医药大学青年科技创新培育计划项目(XQC2024001)。

摘　　要：随着新型多肽药物开发领域的迅猛发展,天然多肽的化学修饰技术备受关注。与传统化学方法相比,有机电化学方法具有条件温和、化学选择性高、原子经济性好等诸多优点,符合绿色化学理念,已广泛应用于有机合成。近年来,该方法在复杂多肽修饰中的应用优势逐步显现。本文介绍了天然多肽的电化学修饰领域的最新进展,重点讨论了相关的实验方法、反应机理以及合成应用。The rapid development of peptide therapeutics has sparked interest in the chemical modification of native peptides.Electrochemical modification has emerged as a promising technique,offering distinct advantages over traditional chemical approaches,including mild reaction conditions,high chemo-selectivity,and high atom efficiency,all of which align with the principles of green chemistry.This approach has found widespread applications in organic synthesis,with significant progress observed in recent years regarding its use in the modification of native peptides.In this review,we introduce the latest advancements in the field of electrochemical modifications of native peptides,focusing on experimental protocols,reaction mechanisms and synthetic applications.

关 键 词：肽 电化学 绿色化学 反应机理 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]