脉冲电场去交感神经防治慢性肝病的潜在方法  

Potential Method for Pulsed Electric Field Ablation of Sympathetic Nerves Against Chronic Liver Disease

作　　者：刘相邑 任志刚[1,2] 胡小波 余祖江[1,2] LIU Xiangyi;REN Zhigang;HU Xiaobo;YU Zujiang(Department of Infectious Diseases,The First Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450052,China;State Key Laboratory of Antiviral Drugs,Zhengzhou University,Zhengzhou Henan 450052,China)

机构地区：[1]郑州大学第一附属医院感染性疾病医学部,河南郑州450052 [2]郑州大学抗病毒性传染病创新药物全国重点实验室,河南郑州450052

出　　处：《中国医疗设备》2025年第4期1-7,18,共8页China Medical Devices

基　　金：国家重点研发计划(2022YFC2303103);国家科技重大专项(2018ZX10301201)。

摘　　要：慢性肝病是我国主要慢性病之一,延缓甚至逆转其病程是一项重大挑战。在慢性肝病发生发展过程中,交感神经系统具有重要作用,可作为慢性肝病防治的靶点。目前,交感神经消融术已应用于多种疾病,这对慢性肝病的治疗具有借鉴意义。作为一项重要的消融技术,依托纳秒脉冲电场实现消融的纳秒刀具有独特优势,可能成为慢性肝病的潜在治疗方案。本文综述了交感神经兴奋与慢性肝病的联系、去交感神经用于疾病治疗的进展、脉冲电场在疾病治疗中的应用,分析了使用脉冲电场防治慢性肝病的可行性,并对脉冲电场应用于慢性肝病治疗的前景及其面临的挑战进行展望和总结,以期为脉冲电场治疗慢性肝病提供理论依据和参考。Chronic liver disease is one of the major chronic diseases in China,and slowing or even reversing its course is a significant challenge.The sympathetic nervous system has an important role in the development of chronic liver disease,which can be used as a target for the prevention and treatment of chronic liver disease.Sympathetic ablation is now being used to treat a wide range of diseases,and this has implications for the treatment of chronic liver disease.As an important ablation technology,the nanosecond knife,which relies on nanosecond pulsed electric fields to achieve ablation,has unique advantages and may be a potential treatment option for chronic liver disease.This paper reviewed the link between sympathetic excitation and chronic liver disease,the progress of ablation of sympathetic nerves for disease treatment,the application of pulsed electric fields in disease treatment,analyzed the feasibility of using pulsed electric fields in the prevention and treatment of chronic liver disease,and looked forward to and summarized the prospects for the application of pulsed electric fields in the treatment of chronic liver disease and the challenges it faces,aimed to provide a theoretical basis and reference for the treatment of chronic liver diseases with pulsed electric fields.

关 键 词：慢性肝病 交感神经系统 纳秒脉冲电场 交感神经消融术 

分 类 号：R575.2[医药卫生—消化系统] R197.3[医药卫生—内科学]