小脑梗死患者脑功能网络的变化及与认知功能的关系研究  

Study on the Changes of Brain Functional Network and Its Relationship with Cognitive Function in Patients with Cerebellar Infarction

作　　者：蒋明清 吴语丝 阮江海 罗华 JIANG Mingqing;WU Yusi;RUAN Jianghai;LUO Hua(Department of Neurology,The Affiliated Hospital of Southwest Medical University,Luzhou Sichuan 646000,China)

机构地区：[1]西南医科大学附属医院神经内科,四川泸州646000

出　　处：《中国医疗设备》2025年第4期132-137,157,共7页China Medical Devices

基　　金：国家自然科学基金青年科学基金(81804198);四川省科技厅重点研发项目(2024YFFK0142)。

摘　　要：目的研究小脑梗死患者基于静息态脑电脑网络连接的改变及其与认知功能的潜在关系。方法对37例小脑梗死患者(小脑梗死组)和40例健康个体(对照组)个体静息状态脑电图数据进行预处理并划分频段:delta(1~4 Hz)、theta(4~8 Hz)、alpha(8~13 Hz)、beta(13~30 Hz)和gamma(30~45 Hz)。通过相位同步分析计算相位锁定值,构建电极导联连接矩阵,计算网络属性参数(小世界指数、聚类系数、局部效率、全局效率和最短路径长度),并评估与认知功能评分的相关性。结果小脑梗死组在delta和gamma频段的功能连接均显著增强(P<0.05),在alpha和beta频段均显著减弱(P<0.05)。在delta频段,小脑梗死组全局效率、局部效率和聚类系数显著增加(P<0.05),小世界指数和最短路径长度显著降低(P<0.05);在alpha和beta频段,小脑梗死组在全局效率、局部效率和聚类系数显著降低(P<0.05),在最短路径长度均显著增加(P<0.05)。在gamma频段,小脑梗死组的局部效率和聚类系数显著高于对照组(P<0.05)。小脑梗死组认知功能量表评分与全局效率、局部效率和聚类系数呈显著正相关(P<0.01),与最短路径长度呈负相关(P<0.01)。结论小脑梗死患者静息态脑网络连接和网络属性异常,与认知功能障碍密切相关,为探索更有效的诊断和治疗策略提供了基础。Objective To investigate the changes in functional connectivity of EEG signals in patients with cerebellar infarction and their relationship with cognitive function.Methods EEG data from 37 cerebellar infarction patients(cerebellar infarction group)and 40 healthy controls(control group)were preprocessed and decomposed into five frequency bands:delta(1-4 Hz),theta(4-8 Hz),alpha(8-13 Hz),beta(13-30 Hz),and gamma(30-45 Hz).Through phase synchronization analysis,the phase locking value was calculated to construct the electrode lead connectivity matrices and compute network attribute parameters,including small-world index,clustering coefficient,local efficiency,global efficiency,shortest path length,and to evaluate the relationships between these network attribute parameters and cognitive function scores.Results The cerebellar infarction group showed significantly increased functional connectivity in the delta and gamma bands(P<0.05)and significantly decreased connectivity in the alpha and beta bands(P<0.05).In the delta band,cerebellar infarction group exhibited significantly increased global efficiency,local efficiency,and clustering coefficient(P<0.05),with considerably decreased small-world index and shortest path length(P<0.05).In the alpha and beta bands,cerebellar infarction group showed significantly reduced global efficiency,local efficiency,and clustering coefficient(P<0.05),with a significantly increased shortest path length(P<0.05).In the gamma band,the local efficiency and clustering coefficient in cerebellar infarction group were significantly higher than those in the control group(P<0.05).Global efficiency,local efficiency,and clustering coefficient were positively correlated with cognitive function scores(P<0.01),while the shortest path length was negatively correlated with cognitive function scores in the cerebellar infarction group(P<0.01).Conclusion Abnormal resting-state brain network connectivity and network attributes in patients with cerebellar infarction are closely related to cognitive dysfunc

关 键 词：小脑梗死 静息态脑网络 脑电图 相位锁定值 图论分析 认知量表评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]