帕金森病伴快速眼动睡眠行为障碍的静息态功能磁共振研究进展  

Research Progress in Resting-State Functional MRI of Parkinson’s Disease with Rapid Eye Movement Sleep Disorder

作　　者：杨媛 高平 YANG Yuan;GAO Ping(Department of Radiology,Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine,Xiangyang Hubei 441000,China;Hubei Provincial Clinical Research Center of Parkinson’s Disease,Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine,Xiangyang Hubei 441000,China)

机构地区：[1]湖北医药学院附属襄阳市第一人民医院放射科,湖北襄阳441000 [2]湖北医药学院附属襄阳市第一人民医院湖北省帕金森病临床医学研究中心,湖北襄阳441000

出　　处：《中国医疗设备》2025年第4期158-163,176,共7页China Medical Devices

基　　金：湖北省科技计划项目重点研发专项(2023BCB140);襄阳市第一人民医院科技创新项目(XYY2023SD16)。

摘　　要：帕金森病(Parkinson’s Disease,PD)是一种进行性神经退行性疾病,以运动症状为主要表现,同时可合并多种非运动症状。约33%~46%的PD患者合并快动眼睡眠行为障碍(Rapid Eye Movement Sleep Behavior Disorder,RBD)。RBD是PD的关键前驱症状之一,其早期出现为PD的早期诊断和早期治疗提供了机会。相较于常规MRI序列基于脑结构的研究,静息态功能磁共振(resting-state functional MRI,rs-fMRI)从脑功能网络层面探索PD合并RBD(PD RBD)患者的神经病理机制,为其诊断及治疗寻找影像学靶点,从而提高患者生活质量、延缓疾病发展并节约治疗成本。本文通过总结rs-fMRI的各种分析方法在PD RBD中的应用进展,以期为PD RBD的精准诊疗提供参考,推动PD RBD诊疗水平的整体提升。Parkinson’s disease(PD)is a progressive neurodegenerative disorder mainly manifested by motor symptoms,and it can also be accompanied by various non-motor symptoms.Approximately 33%-46%of PD patients are comorbid with rapid eye movement sleep behavior disorder(RBD).RBD is one of the key prodromal symptoms of PD,and its early occurrence provides an opportunity for the early diagnosis and early treatment of PD.Compared with the research based on brain structure using conventional MRI sequences,resting-state functional MRI(rs-fMRI)explores the neuropathological mechanisms of patients with PD complicated by RBD(PD RBD)from the perspective of brain functional networks,and searches for imaging targets for its diagnosis and treatment.In this way,it can improve the quality of life of patients,delay the progression of the disease,and reduce treatment costs.This article summarized the application progress of various analysis methods of rs-fMRI in PD RBD,with the hope of providing a reference for the precise diagnosis and treatment of PD RBD and promoting the overall improvement of the diagnosis and treatment level of PD RBD.

关 键 词：帕金森病 快速眼动睡眠行为障碍 静息态功能磁共振 功能连接 影像学靶点 精准诊疗 

分 类 号：R742.5[医药卫生—神经病学与精神病学]