癌症相关成纤维细胞在癌症复发机制中的应用进展  

Advancements in the application of cancer-associated fibroblasts in the mechanism of cancer recurrence

作　　者：林思婷 钟钧琳[1] 苏漫婷 张新玲[1] Lin Siting;Zhong Junlin;Su Manting;Zhang Xinling(Department of Ultrasound,the Third Affiliated Hospital of Sun Yet-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院超声科,广州510630

出　　处：《中华实验外科杂志》2025年第1期164-168,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(91859115)。

摘　　要：癌症复发一直是肿瘤治疗领域的重要挑战和热点问题。癌症相关成纤维细胞是肿瘤微环境中调节肿瘤生长、侵袭和转移的重要成分,对其深入研究有助于更好地理解肿瘤微环境的调节机制,并为癌症复发的预测和治疗策略提供重要的理论基础。本文旨在综述肿瘤微环境中的癌症相关成纤维细胞的特性及其在癌症复发中的作用,以期为临床诊疗提供参考。Cancer recurrence has always been a significant challenge and a hot topic in the field of cancer treatment.Cancer-associated fibroblasts(CAFs)play a crucial role in regulating tumor growth,invasion,and metastasis within the tumor microenvironment(TME).In-depth research on CAFs contributes to a better understanding of TME regulatory mechanisms and provides a theoretical foundation for predicting and developing treatment strategies for cancer recurrence.This article reviews the characteristics of CAFs in the TME and their role in cancer recurrence,in order to provide reference for the clinical diagnosis and treatment.

关 键 词：癌症 癌症相关成纤维细胞 复发 肿瘤微环境 

分 类 号：R730.2[医药卫生—肿瘤]