非小细胞肺癌应用胸腔镜肺癌手术治疗的效果观察  

Effect observation of thoracoscopic lung cancer surgery on non-small cell lung cancer

作　　者：姜寿银 邵万军 张霞 JIANG Shou-yin;SHAO Wan-jun;ZHANG Xia(Dafeng People's Hospital,Yancheng,Yancheng 224100,China)

机构地区：[1]盐城市大丰人民医院,224100

出　　处：《中国实用医药》2025年第6期35-38,共4页China Practical Medicine

摘　　要：目的 探究非小细胞肺癌应用胸腔镜肺癌手术治疗的效果。方法 选取60例非小细胞肺癌患者为研究对象,随机分为对照组(30例)、研究组(30例)。对照组实施两孔胸腔镜手术治疗,研究组实施单孔胸腔镜手术治疗。比较两组手术指标、并发症发生情况及实验室指标[白细胞介素-1(IL-1)、C反应蛋白(CRP)、鳞状细胞癌抗原(SCC-Ag)、前列腺素E_(2)(PGE_(2))]。结果 研究组手术时间(125.41±25.12)min短于对照组(140.65±22.36)min(t=2.482,P=0.016<0.05);研究组术中出血量(105.34±20.26)ml比对照组的(121.87±25.54)ml少(t=2.777,P=0.007<0.05);研究组视觉模拟评分法(VAS)评分(3.27±1.41)分比对照组的(4.17±1.29)分低(t=2.579,P=0.012<0.05);研究组住院时间(7.87±1.44)d比对照组的(8.88±1.54)d短(t=2.624,P=0.011<0.05)。两组并发症发生率比较差异不大(χ^(2)=1.071,P=0.301>0.05)。研究组IL-1(10.88±2.13)ng/L、CRP(10.42±2.16)mg/L、SCC-Ag(1.42±0.16)ng/ml、PGE_(2)(138.61±45.88)pmol/L明显较对照组的(21.34±4.27)ng/L、(17.35±3.65)mg/L、(1.84±0.24)ng/ml、(224.37±52.41)pmol/L低(P<0.05)。结论 在非小细胞肺癌患者治疗中,单孔胸腔镜手术治疗在缩减手术时间、减少术中出血量及减轻术后疼痛方面有显著优势,较两孔胸腔镜手术对患者造成的创伤与疼痛应激更小,并发症更少,更有利于患者的术后康复。Objective To explore the effect of thoracoscopic lung cancer surgery on non-small cell lung cancer.Methods 60 patients with non-small cell lung cancer were selected as the study subjects and randomly divided into a control group (30 cases) and a study group (30 cases).The control group underwent two-port thoracoscopic surgery,and the study group underwent single-port thoracoscopic surgery.The surgical indicators,complications and laboratory indicators[interleukin-1 (IL-1),C-reactive protein (CRP),squamous cell carcinoma antigen (SCC-Ag),prostaglandin E_(2) (PGE_(2))]were compared between the two groups.Results The operation time of (125.41±25.12) min in the study group was shorter than (140.65±22.36) min in the control group (t=2.482,P=0.016<0.05).The intraoperative blood loss of (105.34±20.26) ml in the study group was less than (121.87±25.54) ml in the control group (t=2.777,P=0.007<0.05).The visual analogue scale (VAS)score of (3.27±1.41) points in the study group was lower than (4.17±1.29) points in the control group (t=2.579,P=0.012<0.05).The length of hospital stay in the study group was (7.87±1.44) d,which was shorter than(8.88±1.54) d in the control group (t=2.624,P=0.011<0.05).There was no significant difference in the incidence of complications between the two groups (χ^(2)=1.071,P=0.301>0.05).The study group had IL-1 of (10.88±2.13) ng/L,CRP of (10.42±2.16) mg/L,SCC-Ag of (1.42±0.16) ng/ml,and PGE_(2) of (138.61±45.88) pmol/L,which were significantly lower than (21.34±4.27) ng/L,(17.35±3.65) mg/L,(1.84±0.24) ng/ml,and(224.37±52.41) pmol/L in the control group (P<0.05).Conclusion In the treatment of patients with nonsmall cell lung cancer,single-port thoracoscopic surgery has significant advantages in shortening operation time,reducing intraoperative blood loss and postoperative pain.Compared with two-port thoracoscopic surgery,it causes less trauma,smaller pain stress,fewer complications,and is more conducive to postoperative rehabilitation of patients.

关 键 词：非小细胞肺癌 肺癌手术 单孔胸腔镜 两孔胸腔镜 治疗效果 

分 类 号：R734.2[医药卫生—肿瘤]