重症精神病患者甲状腺功能检查的临床价值分析  

Analysis of clinical value of thyroid function examination in patients with severe mental illness

作　　者：束明旻 SHU Ming-min(Department of Clinical Laboratory,The Second People's Hospital of Dafeng District,Yancheng 224100,China)

机构地区：[1]江苏省盐城市大丰区第二人民医院检验科,224100

出　　处：《中国实用医药》2025年第6期91-94,共4页China Practical Medicine

摘　　要：目的 分析重症精神病患者甲状腺功能检查的临床价值。方法 选取69例重症精神病患者,根据是否合并甲状腺功能异常将其分为甲状腺功能亢进症(甲亢)组(合并甲亢)、甲状腺功能减退(甲减)组(合并甲减)、对照组(单纯重症精神病),每组23例。三组均进行甲状腺功能检查。对比三组甲状腺功能指标[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)、三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))]检验值与阳性检出率。结果 甲亢组的FT_(3)、FT_(4)、TSH、T_(3)、T_(4)水平分别为(12.43±2.74)pmol/L、(35.78±5.23)pmol/L、(0.23±0.04)m IU/ml、(4.74±0.58)ng/ml、(30.14±2.83)μg/dl,甲减组的FT_(3)、FT_(4)、TSH、T_(3)、T_(4)水平分别为(2.01±0.35)pmol/L、(6.26±1.46)pmol/L、(30.63±3.67)m IU/ml、(0.63±0.16)ng/ml、(3.45±0.68)μg/dl,对照组的FT_(3)、FT_(4)、TSH、T_(3)、T_(4)水平分别为(5.60±0.34)pmol/L、(15.52±1.58)pmol/L、(2.75±0.32)m IU/ml、(1.58±0.25)ng/ml、(9.33±1.17)μg/dl;甲亢组的FT_(3)、FT_(4)、T_(3)、T_(4)水平均高于对照组,TSH水平低于对照组(P<0.05);甲减组的FT_(3)、FT_(4)、T_(3)、T_(4)水平均低于对照组,TSH水平高于对照组(P<0.05)。甲亢组和甲减组FT_(3)、FT_(4)、TSH、T_(3)、T_(4)阳性检出率分别为82.61%、86.96%、91.30%、91.30%、82.61%和91.30%、91.30%、82.61%、78.26%、86.96%,均高于对照组的4.35%、13.04%、4.35%、8.70%、4.35%(P<0.05)。结论 单纯重症精神病患者并不会导致甲状腺功能异常,只有重症精神病合并甲亢或甲减时才会检测出甲状腺功能指标异常,对重症精神病患者进行甲状腺功能检测有助于及时发现甲亢或甲减。Objective To analyze the clinical value of thyroid function examination in patients with severe mental illness.Methods 69 patients with severe mental illness were selected and divided into hyperthyroidism group (combined with hyperthyroidism),hypothyroidism group (combined with hypothyroidism),and control group(simple severe mental illness) according to whether they were combined with thyroid dysfunction,with 23 cases in each group.Thyroid function tests were performed in all three groups.The thyroid function indexes[free triiodothyronine (FT_(3)),free thyroxine (FT_(4)),thyroid-stimulating hormone (TSH),triiodothyronine (T_(3)),thyroxine(T_(4))]and positive detection rates were compared among the three groups.Results In hyperthyroidism group,the levels of FT_(3),FT_(4),TSH,T_(3) and T_(4) were (12.43±2.74) pmol/L,(35.78±5.23) pmol/L,(0.23±0.04) m IU/ml,(4.74±0.58) ng/ml and (30.14±2.83)μg/dl;in hypothyroidism group,the levels of FT_(3),FT_(4),TSH,T_(3) and T_(4) were(2.01±0.35) pmol/L,(6.26±1.46) pmol/L,(30.63±3.67) m IU/ml,(0.63±0.16) ng/ml and (3.45±0.68)μg/dl;in control group,the levels of FT_(3),FT_(4),TSH,T_(3) and T_(4) were (5.60±0.34) pmol/L,(15.52±1.58) pmol/L,(2.75±0.32) m IU/ml,(1.58±0.25) ng/ml and (9.33±1.17)μg/dl.The levels of FT_(3),FT_(4),T_(3) and T_(4) in hyperthyroidism group were higher than those in control group,and the level of TSH was lower than that in control group (P<0.05).The levels of FT_(3),FT_(4),T_(3) and T_(4) in hypothyroidism group were lower than those in control group,and TSH level was higher than that in control group (P<0.05).The positive rates of FT_(3),FT_(4),TSH,T_(3) and T_(4) were 82.61%,86.96%,91.30%,91.30%and 82.61%in hyperthyroidism group,and 91.30%,91.30%,82.61%,78.26%and86.96%in hypothyroidism group,which were higher than 4.35%,13.04%,4.35%,8.70%and 4.35%in control group (P<0.05).Conclusion Simple severe mental illness does not lead to thyroid dysfunction.Abnormal thyroid function indicators can only be detected when severe mental illness is comb

关 键 词：重症精神病 甲状腺功能检查 甲状腺功能异常 临床价值 

分 类 号：R749[医药卫生—神经病学与精神病学]