胞磷胆碱联合丁苯酞对急性脑梗死患者血流动力学及血清相关因子水平的影响  

Effects of citicoline combined with butylphthalein on hemodynamicsand serum related factors in patients with acute cerebral infarction

作　　者：周志明 孙东辉 鲁国杰 ZHOU Zhiming;SUN Donghui;LU Guojie(Department of Neurology,Zhumadian First People's Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市第一人民医院神经内科,河南驻马店463000

出　　处：《黑龙江医药科学》2025年第4期12-15,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关联合共建项目,编号:LHGJ20223440。

摘　　要：目的:探究胞磷胆碱联合丁苯酞对急性脑梗死(ACI)患者血流动力学及血清相关因子水平的影响。方法:选取2022年5月至2023年9月驻马店市第一人民医院就诊的ACI患者87例,根据治疗方法不同分为对照组、联合组。其中予以丁苯酞的44例为对照组,予以胞磷胆碱+丁苯酞的43例为联合组。比较两组临床疗效、不良反应发生率、治疗前后神经功能[脑源性神经营养因子(BDNF)、神经生长因子(NGF)、同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)]、血流动力学[最大峰值流速(PSV)、搏动指数(PI)、舒张末期流速(EDV)、阻力指数(RI)]及血清相关因子[超敏C反应蛋白(hs-CRP)、基质金属蛋白酶(MMP)-9、白介素(IL)-6、正五聚蛋白(PTX)3]水平。结果:联合组临床总有效率93.02%高于对照组77.27%(P<0.05);联合组治疗后神经功能、血流动力学、血清相关因子改善程度均优于对照组(P<0.05);两组不良反应发生率比较,无显著差异(P>0.05)。结论:胞磷胆碱联合丁苯酞治疗ACI疗效显著,可改善神经功能,调节血流动力学,减轻体内炎症反应,并具有一定安全性。Objective:To investigate the effects of citicoline combined with butylphthalein on hemodynamics and serum related factors in patients with acute cerebral infarction(ACI).Methods:A total of 87 ACI patients from May 2022 to September 2023 in Zhumadian First People's Hospital were selected and divided into control group and combination group according to different treatment methods.Among them,44 cases were treated with butylphthalein as control group and 43 cases were treated with citicoline+butylphthalein as combination group.Compare the clinical efficacy,incidence of adverse reactions of the two groups,as well as the levels of neurofunctional factors[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),homocysteine(Hcy),and neuron specific enolase(NSE)],hemodynamic parameters[maximum peak systolic velocity(PSV),pulsatility index(PI),end diastolic velocity(EDV),resistance index(RI)]and serum related factors[high sensitivity C reactive protein(hs-CRP),matrix metalloproteinase(MMP)-9,interleukin(IL)-6,pentraxin 3]before and after treatment.Results:The total clinical effective rate of the combined group was 93.02%,which was higher than that of the control group 77.27%(P<0.05).The improvement of neurological function,hemodynamics and serum related factors in the combined group were superior to those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Citicoline combined with butylphthalein is effective in the treatment of ACI,which can improve nerve function,regulate hemodynamics,reduce inflammation in vivo,and has certain safety.

关 键 词：胞磷胆碱 丁苯酞 急性脑梗死 血流动力学 血清相关因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]