结肠癌与结肠腺瘤肠道菌群数量及失调比的差异性分析  

Difference analysis of intestinal flora quantity and imbalance ratio between colon cancer and colorectal adenoma

作　　者：李佳 金雪琴[1] 吴兵[1] 王姜明[1] LI Jia;JIN Xue-Qin;WU Bing(Department of Gastroenterology,Wuzhong People's Hospital of Suzhou City,Suzhou 215100,Jiangsu,China)

机构地区：[1]苏州市吴中人民医院消化内科,江苏苏州215100

出　　处：《吉林医学》2025年第4期795-798,共4页Jilin Medical Journal

基　　金：2022年度苏州市吴中区科技计划项目(2022年度)。

摘　　要：目的:探究结肠癌与结肠腺瘤肠道菌群数量及失调比的差异性。方法:选取2022年6月~2024年6月苏州市吴中人民医院收治的120例结肠癌患者作为试验组,选择同期150例结肠腺瘤患者作为对照2组,另选择同期健康人群150例作为对照1组,对比三组患者的菌群数量及肠道菌群多样性。结果:对照1组、对照2组及试验组的大肠杆菌、粪肠球菌定量呈上升趋势,弯曲杆菌、双歧杆菌、乳酸杆菌的定量呈下降趋势,差异均有统计学意义(P<0.05);试验组的大肠杆菌、粪肠球菌的定量均高于对照1组和对照2组,弯曲杆菌、双歧杆菌、乳酸杆菌的定量均低于对照1组和对照2组,差异均有统计学意义(P<0.05)。试验组的shanno、Chao指数均低于对照1组和对照2组,对照2组的shanno、Chao指数均低于对照1组,差异均有统计学意义(P<0.05)。结论:结肠癌的菌群失调比及菌群多样性与结肠腺瘤存在差异性,结肠癌的菌群失调比更严重,检测患者肠道菌群数量可为诊断结肠癌提供参考依据。Objective To investigate the effects of different controlled antihypertensive methods on inflammatory factors and pain after endoscopy-assisted lumbar fusion in large channel spine(Endo-P/TLIF under Delta channel).Methods 90 patients admitted to our hospital from August 2023 to March 2024 who underwent Endo-P/TLIF under Delta channel were selected and divided into a control group and observation group by random number method(n=30).The control group was treated with anesthetic drugs to control hypotension,and the observation group was treated with vasoactive drugs to control hypotension.Clinical indicators,levels of inflammatory factors,analgesic effect,and adverse reactions were evaluated.Results The amount of anesthetic drugs,intraoperative blood loss,and operation time in the observation group were lower than in the control group(P<0.05).The levels of IL-6 and TNF-α in the 2 groups were higher than before controlled hypotension and 1 hour after surgery(P<0.05).However,the levels of IL-6 and TNF-αin the observation group were lower than those in the control group before hypotension and 1 hour after surgery(P<0.05).The IL-10 level in the observation group was higher than in the control group before the end of controlled hypotension and 1 hour after surgery(P<0.05).The levels of SBP and DBP in the combination group at T1 were lower than those at T0(P<0.05).However,there was no significant difference between the levels of SBP and DBP at T0 and T2(P>0.05),while there was no significant difference between the levels of SBP and DBP at T0,T1 and T2(P>0.05).The levels of MAP and HR in the control group at T1 and T2 were lower than those at T0,but there was no significant difference in the levels of MAP and HR in the combination group at T0,T1,and T2(P>0.05).VAS scores in the observation group were lower than those in the control group 30 minutes and 1 hour after operation(P<0.05).The incidence of adverse reactions in the observation group was lower than in the control group(P<0.05).Conclusions Compared with anesthesia

关 键 词：结肠癌 结肠腺瘤 肠道菌群数量 失调比 

分 类 号：R735.35[医药卫生—肿瘤]