结肠镜联合C反应蛋白水平对溃疡性结肠炎患者疾病活动度的评估价值  

Evaluation value of colonoscopy combined with CRP level on disease activity of patients with ulcerative colitis

作　　者：杨婷[1] YANG-Ting(Department of Gastroenterology,981 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army,Chengde 067000,Hebei,China)

机构地区：[1]中国人民解放军联勤保障部队第九八一医院消化内科,河北承德067000

出　　处：《吉林医学》2025年第4期824-827,共4页Jilin Medical Journal

基　　金：河南省医学科技攻关计划联合共建项目[项目编号:LHGJ20210539]。

摘　　要：目的:分析结肠镜联合C反应蛋白(CRP)水平对溃疡性结肠炎(UC)患者疾病活动度的评估价值。方法:回顾分析120例于2018年10月~2023年10月在中国人民解放军联勤保障部队第九八一医院就诊的UC患者的临床资料,同时招募98例体检健康人士,分别设为研究组与对照组。比较两组结肠镜及CRP水平,分析研究组临床资料,采用多元线性分析影响UC患者疾病活动度的独立因素,以受试者工作特征(ROC)曲线评价结肠镜联合CRP对UC患者疾病活动度的评估价值。结果:研究组CRP水平高于对照组,差异有统计学意义(P<0.05)。研究组患者活动度良好占比81.67%,活动度不佳占比18.33%;活动度不佳与活动度良好患者年龄、体重指数(BMI)、性别、饮酒、吸烟、总胆固醇(TC)水平、三酰甘油(TG)水平、胆酐(Cr)水平、高密度脂蛋白胆固醇(HDL)比较,差异无统计学意义(P>0.05),活动度不佳和活动度良好患者CRP水平比较差异有统计学意义(P<0.05),结肠镜检查活动度不佳占比高于活动度良好,差异有统计学意义(P<0.05)。CRP水平与患者预后显著相关(OR=3.995,P<0.05),结肠镜诊断UC的AUC为0.837(95%CI:0.774~0.906),灵敏度为81.82%,特异度为77.01%;CRP诊断UC的AUC为0.818(95%CI:0.721~0.892),灵敏度为90.91%,特异度为52.87%;二者联合诊断UC的AUC为0.884(95%CI:0.799~0.943),灵敏度为72.73%,特异度为97.70%。结肠镜与CRP水平二者联合诊断UC的价值高于二者单一诊断价值。结论:结肠镜联合CRP水平对UC患者疾病活动度的价值较高。Objective To analyze the value of colonoscopy combined with C-reactive protein(CRP)in evaluating the disease activity of patients with ulcerative colitis.Methods The clinical data of 120 UC patients who were treated in the 981 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from October 2018 to October 2023 were retrospectively analyzed,and 98 healthy individuals who were recruited for physical examination in our hospital.All of them were recorded as the study group and the control group respectively.The levels of colonoscopy and CRP were compared between the two groups,the clinical data of the study group were analyzed,and the independent factors affecting the disease activity of UC patients were analyzed by multivariate linear analysis.The receiver operating characteristic curve(ROC)was used to evaluate the value of colonoscopy combined with CRP on the disease activity of UC patients.Results The CRP level of the study group was higher than that of the control group(P>0.05).82%of the patients in the study group had good activity,and 18%had poor activity.There was no statistical significance in age,BMI,gender,alcohol consumption,smoking,TC level,TG level,CR level,and HDL between the patients with poor activity and those with good activity(P>0.05).There was statistical significance in CRP level between patients with poor activity and good activity(P<0.05),and the proportion of patients with poor activity in colonoscopy was higher than that with good activity(P<0.05).The combination of colonoscopy and CRP was significantly related to the prognosis of patients(OR=3.995,P<0.05).There was a substantial correlation between CRP levels and patient outcome(OR=3.995,P<0.05).The AUC of colonoscopy for diagnosing UC was 0.837(95%CI:0.774~0.906),with a sensitivity of 81.82%and a specificity of 77.01%.When using CRP to diagnose UC,the sensitivity was 90.91%,the specificity was 52.87%,and the AUC was 0.818(95%CI:0.721~0.892).The AUC for the combined diagnosis of UC was 0.884(95%CI:0.799 to

关 键 词：结肠镜 C反应蛋白 溃疡性结肠炎 灵敏度 活动度 

分 类 号：R574.62[医药卫生—消化系统]