MAFLD与遗传易感性的相关研究  

The Correlation between MAFLD and Genetic Susceptibility

作　　者：付梦微 张宁 Mengwei Fu;Ning Zhang(The First Clinical College of Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000;Ganzhou People's Hospital,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医科大学第一临床医学院,江西赣州341000 [2]赣州市人民医院,江西赣州341000

出　　处：《医学研究前沿》2025年第3期35-37,共3页Frontiers of Medical Research

基　　金：江西省自然科学基金项目,20242BAB25440,DNA甲基化修饰CSE调控TGF-β/Smads信号通路在肝纤维化发展机制中的研究。

摘　　要：代谢相关性脂肪性肝病(MAFLD)是以肝脂肪变性为主要病理表现的一组临床综合征,其发病率呈逐年上升趋势,已经成为全球范围内最常见的慢性肝病,给患者及社会带来了沉重的医疗负担。其发病机制复杂,涉及多种因素。遗传易感性在MAFLD发病中起重要作用。该文就代谢相关脂肪性肝病与遗传易感相关因子PNPLA3、TM6SF2、GCKR、MBOAT7之间的关系作一综述。Metabolic related fatty liver disease(MAFLD)is a group of clinical syndromes with hepatic steatosis as the main pathological manifestation.The incidence of MAFLD is increasing year by year,and it has become the most common chronic liver disease worldwide,bringing heavy medical burden to patients and society.Its pathogenesis is complex and involves many factors.Genetic susceptibility plays an important role in the pathogenesis of MAFLD.This article reviews the relationship between metabolism-related fatty liver disease and genetic susceptibility factors PNPLA3,TM6SF2,GCKR and MBOAT7.

关 键 词：代谢相关性脂肪性肝病 遗传易感性 PNPLA3 TM6SF2 GCKR MBOAT7 

分 类 号：R575.5[医药卫生—消化系统]