伽马刀放射疗法治疗非典型脑膜瘤患者术后生存及预后的影响因素分析  

Analysis of Infl uencing Factors of Gamma-Knife Radiotherapy on Postoperative Survival and Prognosis in Patients with Atypical Meningioma

作　　者：伊力亚尔·艾海提 付强[2] 吴昊[2] 王泽宁 马晓鹏 周庆九[1,2] Yiliyaer·Aihaiti;Fu Qiang;Wu Hao;Wang Zening;Ma Xiaopeng;Zhou Qingjiu(The First Clinical Medical College of Xinjiang Medical University,Urumqi,Xinjiang 830054;The First Department of Neurosurgery,The First Affi liated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054)

机构地区：[1]新疆医科大学第一临床医学院,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院神经外一科,新疆乌鲁木齐830054

出　　处：《科技与健康》2025年第4期5-8,共4页Technology and Health

摘　　要：探讨分析非典型脑膜瘤(atypical meningiomas,AM)患者术后生存的影响因素。回顾性分析2010年1月—2019年12月于新疆医科大学第一附属医院行手术治疗且术后病理诊断为AM的110例患者的临床资料并定期随访,随访时间为[4(1,6)]年,根据AM是否复发将其分为复发组和未复发组,分析影响AM患者术后复发的危险因素。单因素分析结果显示,伽马刀放射疗法、切除程度与AM术后复发相关(P<0.05);生存分析结果表明,是否采取伽马刀放射疗法患者的生存变化趋势比较,差异有统计学意义(P_(log Rank)<0.05)。研究发现,AM具有发病率低但复发率较高的特点,目前仍然是临床治疗的一个难题。手术全切为该病首选的治疗方式,未行伽马刀放射疗法是导致AM患者术后复发的危险因素,对于未行全切手术患者,术后应及早开展伽马刀放射疗法。To explore and analyze the influencing factors of postoperative survival in patients with atypical meningioma(AM).The clinical data of 110 patients who underwent surgical treatment in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to December 2019 and were pathologically diagnosed as AM after surgery were retrospectively analyzed and followed up regularly for[4(1,6)]years.According to whether AM recurred,they were divided into a recurrence group and a non-recurrence group.The risk factors affecting the postoperative recurrence of AM patients were analyzed.The results of univariate analysis showed that gamma-knife radiotherapy and the extent of resection were related to the postoperative recurrence of AM(P<0.05);the results of survival analysis showed that there was a statistically significant difference in the survival change trend between patients with and without gamma-knife radiotherapy(P_(log Rank)<0.05).It was found that AM is characterized by low incidence but high recurrence rate,and it is still a difficult problem in clinical treatment.Total surgical resection is the preferred treatment method for this disease.The absence of gamma-knife radiotherapy is a risk factor for postoperative recurrence in AM patients.For patients who have not undergone total resection,gamma-knife radiotherapy should be carried out as early as possible after surgery.

关 键 词：非典型脑膜瘤 复发 危险因素 放疗 

分 类 号：R739.45[医药卫生—肿瘤]