Current Advances of Artificial Ligaments for Anterior Cruciate Ligament Reconstruction:From Biocompatibility to Bioactivity  

作　　者：Haozhi Zhang Xin Chen Michael Tim-Yun Ong Lei Lei Lizhen Zheng Bingyang Dai Wenxue Tong Bruma Sai-Chuen Fu Jiankun Xu Patrick Shu-Hang Yung Ling Qin 

机构地区：[1]Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Drug Translational Research Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Hong Kong 999077,China [2]The Sir Yue-Kong Pao Cancer Centre,Prince of Wales Hospital,The Chinese University of Hong Kong,Hong Kong 999077,China

出　　处：《Engineering》2025年第3期47-59,共13页工程(英文)

基　　金：supported by the Areas of Excellence Scheme(AoE/M402/20);the Knowledge Transfer Project Fund(KPF24GWP05);the IdeaBooster Fund(IDBF24MED12);the HKSTP Ideation Fund(Ideation 23-0698);the ITC Technology Startup Support Scheme for Universities(TSU24MED05).

摘　　要：Anterior cruciate ligament(ACL)injuries are frequently caused by sports injuries and trauma.In cases involving complete tears,ACL reconstruction(ACLR)surgery is the only way to restore the ligament’s integrity.When selecting a graft,both the potential complications and the mechanical properties and healing efficacies should be considered.Artificial ligaments have been widely applied in clinical ACLR,and most have exhibited satisfactory biocompatibility and short-term follow-up results.Compared with autografts and allografts,however,the lack of bioactivity of currently available artificial ligaments is a major disadvantage.In addition,some long-term follow-up results have revealed other drawbacks of artificial ligaments,such as graft failure and other complications.Here,we summarize attempts to enhance the bioactive performance of artificial ligaments,as such modifications may have good potential for clinical translation and could improve the long-term outcomes of existing products.

关 键 词：Anterior cruciate ligament reconstruction Artificial ligament BIOMATERIALS Graft-bone integration Intra-articular tissue remodeling 

分 类 号：R687.4[医药卫生—骨科学]