Ultrasound-Enabled Nanomedicine for Tumor Theranostics  

作　　者：Kairui Liu Boyuan Jing Jun Kang Lei Han Jin Chang 

机构地区：[1]School of Life Sciences,Tianjin University,Tianjin 300072,China [2]Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures,School of Life Sciences,Tianjin University,Tianjin 300072,China [3]Tianjin Neurological Institute,Key Laboratory of Post-Neuro Injury Neuro-Repair and Regeneration in Central Nervous System,Ministry of Education and Tianjin City,Tianjin Medical University General Hospital,Tianjin 300052,China

出　　处：《Engineering》2025年第3期101-129,共29页工程(英文)

基　　金：financially supported by the National Natural Science Foundation of China(32271440);the Tianjin Health Research Project(TJWJ2023ZD001).

摘　　要：Ultrasound-enabled nanomedicine leverages ultrasound to amplify the capabilities of engineered nanosystems,paving the way for innovative diagnostic and therapeutic breakthroughs in conventional nanomedicine.As a burgeoning discipline,past overviews have sometimes offered a fragmented perspective,lacking a comprehensive view.This review presents a systematic exploration of the latest advancements in ultrasound-enabled nanomedicine,with a particular emphasis on oncology.Covered topics include molecular imaging of tumors,separation of tumor markers,penetration through physiological barriers,perforation of cell membranes,targeted drug release and activation strategies,and an array of sonotherapies for oncological treatments.We delve into the research framework of each topic,the foundational design of the nanosystems,and their associated ultrasound activation mechanisms.Moreover,we highlight recent pivotal research aimed at deepening the reader’s understanding of this intricate domain.This review underscores the integration of design and foundational theories within ultrasound-enabled nanomedicine,aspiring to ignite advanced theoretical insights and introduce innovative design paradigms.In conclusion,we outline current challenges and prospective research directions.An enhanced focus on these areas will expedite the advancement of ultrasound-enabled nanomedicine.

关 键 词：ULTRASOUND NANOMEDICINE Tumor diagnosis Drug delivery Tumor therapy 

分 类 号：R730.5[医药卫生—肿瘤]