Breg细胞在肿瘤免疫逃逸中的机制及相关治疗靶点  

Mechanism of Breg cell in tumor immune escape and related therapeutic targets

作　　者：王熙博 田宝文 陈士巧 Wang Xibo;Tian Baowen;Chen Shiqiao(Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China;Second Clinical Medicine School,Shandong University,Jinan 250033,China;Department of General Surgery(Hepatobiliary Surgery),Qilu Hospital of Shandong University,Jinan 250013,China;Department of Interventional Diagnosis and Treatment,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东大学附属山东省立医院,济南250021 [2]山东大学第二临床学院,济南250033 [3]山东大学齐鲁医院普通外科(肝胆外科),济南250013 [4]山东第一医科大学附属省立医院介入诊疗科,济南250021

出　　处：《国际肿瘤学杂志》2025年第2期107-112,共6页Journal of International Oncology

基　　金：山东省自然科学基金(ZR2021MH065);国家级大学生创新创业训练计划(202310422024)。

摘　　要：肿瘤细胞能够逃避免疫系统的监视和攻击,即产生免疫逃逸;近年来调节性B(Breg)细胞在肿瘤免疫研究中备受瞩目。Breg细胞通过分泌多种细胞因子,在肿瘤免疫逃逸中发挥作用,该领域的机制研究已取得一定成果,对于肿瘤的临床治疗提供了更多靶点和思路,但Breg细胞的表型分类及其在肿瘤免疫中的复杂机制仍有待于系统解析。Tumor cells can escape the surveillance and attack of the immune system,namely immune escape.In recent years,regulatory B(Breg)cell have attracted much attention in researches about tumor immunity.Breg cell plays an important role in tumor immune escape by secreted various cytokines.Mechanistic progress has been made in this field,which provides more targets and ideas for tumor clinical treatment.However,the phenotypic classification of Breg cells and its complex mechanism in tumor immunity still need to be systematically analyzed.

关 键 词：B淋巴细胞 调节性 肿瘤微环境 细胞因子类 T淋巴细胞 免疫疗法 

分 类 号：R730.3[医药卫生—肿瘤]