阿利西尤单抗联合依折麦布治疗老年急性脑梗死合并高脂血症的效果研究  

Clinical effect of alirocumab combined with ezetimibe in the treatment of acute cerebral infarction complicated by hyperlipidemia in the elderly

作　　者：张艳军 王晓丽 董萌 杨丽霞 Zhang Yan-jun;Wang Xiao-li;Dong Meng;Yang Li-xia(Department of Encephalopathy,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300100,China;Institute of Neurotraumatology,Special Medical Center of Chinese People's Armed Police Force,Tianjin 300162,China)

机构地区：[1]天津市中医药研究院附属医院脑病三科,天津300100 [2]中国人民武装警察部队特色医学中心神经创伤修复科,天津300162

出　　处：《中国现代医学杂志》2025年第8期50-54,共5页China Journal of Modern Medicine

基　　金：天津市自然科学基金(No:SJCYBJC27800)。

摘　　要：目的 分析阿利西尤单抗联合依折麦布治疗老年急性脑梗死合并高脂血症的效果。方法 回顾性分析2022年1月—2023年12月天津市中医药研究院附属医院和中国人民武装警察部队特色医学中心收治的138例老年急性脑梗死合并高脂血症的临床资料,按照治疗方法的不同分为对照组(采用依折麦布,70例)和观察组(采用依折麦布+阿利西尤单抗,68例)。评估患者治疗2个月的临床疗效、不良反应,并统计治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、血脂及神经指标[非高密度脂蛋白胆固醇(non-HDL-C)、载脂蛋白B (ApoB)、载脂蛋白A1 (ApoA1)、S100β蛋白]水平。结果 观察组总有效率(98.53%)高于对照组(88.57%)(P <0.05)。观察组治疗前后NIHSS评分及non-HDL-C、ApoB、ApoA1、S100β蛋白的差值均高于对照组(P <0.05)。观察组与对照组不良反应总发生率(16.18%VS 11.43%)比较,差异无统计学意义(P>0.05)。结论 阿利西尤单抗联合依折麦布治疗老年急性脑梗死合并高脂血症疗效显著,可改善脂代谢,促进神经功能的恢复,且安全性较高。Objective To analyze the effect of alirocumab combined with ezetimibe in the treatment of acute cerebral infarction complicated by hyperlipidemia in the elderly.Methods The clinical data of 138 elderly patients with acute cerebral infarction complicated by hyperlipidemia admitted to our hospitals during January 2022 to December 2023 were retrospectively analyzed.According to different treatment methods,they were divided into the control group(n = 70,ezetimibe) and the observation group(n = 68,ezetimibe plus alirocumab).The clinical efficacy and adverse reactions were evaluated after 2 months of treatment.The National Institutes of Health Stroke Scale(NIHSS) scores,and levels of blood lipids and neurological indicators [non-high-density lipoprotein cholesterol(non-HDL-C),apolipoprotein B(ApoB),apolipoprotein A1(ApoA1),S100β protein] were measured before and after treatment.Results The overall effective rate in the observation group(98.53%) was higher than that of the control group(88.57%)(P < 0.05).The differences in NIHSS scores and levels of non-HDL-C,ApoB,ApoA1 and S100β protein before and after treatment in the observation group were all higher than those in the control group(P < 0.05).There was no significant difference in the overall incidence of adverse reactions between the observation group(16.18%) and the control group(11.43%)(P > 0.05).Conclusion Alirocumab combined with ezetimibe shows significant efficacy in treating elderly patients with acute cerebral infarction complicated by hyperlipidemia.It improves lipid metabolism and promotes neurological recovery with a high safety profile.

关 键 词：急性脑梗死 高脂血症 老年 阿利西尤单抗 依折麦布 

分 类 号：R743.33[医药卫生—神经病学与精神病学]