南安北部片区早期结直肠癌伺机性筛查结果分析  

Analysis of Opportunistic Screening Results for Early Colorectal Cancer in the Northern Area of Nan'an

作　　者：黄延波[1] 戴小红 蔡小红 陈坤海 吴叻荣 曹加寿 HUANG Yanbo;DAI Xiaohong;CAI Xiaohong;CHEN Kunhai;WU Lerong;CAO Jiashou(Department of Gastroenterology,Quanzhou Guangqian Hospital,Fujian Province,Quanzhou Fujian 362321,China;Digestive Endoscopy Center,Quanzhou Guangqian Hospital,Fujian Province,Quanzhou Fujian 362321,China)

机构地区：[1]福建省泉州市光前医院消化内科,福建南安362321 [2]福建省泉州市光前医院消化内镜中心,福建南安362321

出　　处：《中国卫生标准管理》2025年第5期103-106,共4页China Health Standard Management

基　　金：泉州市科学技术局2022年医疗卫生领域指导性科技计划项目(2022N021S)。

摘　　要：目的分析南安北部片区早期结直肠癌伺机性筛查结果,为结直肠癌防治提供参考资料。方法研究选择2023年1—6月南安北部片区≥40岁来院就诊及体检人员,发放并签订《早期结直肠癌筛查知情同意书》,共1651例人员参与筛查,实际完成伺机筛查1490例。统计分析伺机筛查和癌症检出情况,基于logistic回归性分析高危因素A~F与结直肠癌发生的关系。结果在完成伺机筛查的1490例人员中,共筛查出结直肠癌高危者439例(男214例、女225例),共544个高危因素,其中高危因素A、B、C、D、E、F分别有7、57、69、326、26、59例,高危因素D占比最高,为60.29%。共检出结直肠癌17例。从癌症分期看,早期结直肠癌6例(35.29%)低于进展期恶性肿瘤11例(64.71%)。从癌症类型看,直肠癌12例(70.59%)高于结肠癌4例(23.53%)、淋巴癌1例(5.88%),不同分期的癌症类型构成情况比较差异无统计学意义(P>0.05)。在439例结直肠癌高危者中,检出结直肠癌17例(高危因素32个)、未检出结直肠癌422例(高危因素512个)。未检出结直肠癌组患者的高危因素A、B筛出率为0.95%、11.85%,低于结直肠癌组患者的17.65%、35.29%,差异有统计学意义(P<0.05),并经logistic回归性分析得出,高危因素A、B是结直肠癌发生的独立危险因素(OR=5.038、4.614)。结论有结直肠癌家族史的直系亲属、有结直肠息肉家族史的直系亲属为结直肠癌的独立危险因素,上述群体应切实做好定期筛查检查工作,及时开展预防措施,做到早预防、早发现、早治疗。Objective To analyze the opportunistic screening results of early colorectal cancer in the northern area of Nan'an,and provide reference materials for the prevention and treatment of colorectal cancer. Methods The study selected 1 651 individuals aged ≥ 40 years from the northern area of Nan'an who came to the hospital for medical treatment and physical examination from January to June 2023, and issued and signed the "Informed Consent Form for Early Colorectal Cancer Screening". A total of 1 490 individuals participated in the opportunistic screening and completed the screening as needed. Statistical analysis of opportunistic screening and cancer detection, and logistic regression analysis of the relationship between high-risk factors A to F and the occurrence of colorectal cancer. Results Among the 1 490 individuals who completed the opportunistic screening, a total of 439 high-risk individuals for colorectal cancer were identified (214 males and 225 females), with 544 high-risk factors identified. Among them, high-risk factors A to F accounted for 7, 57, 69, 326, 26, and 59 cases, respectively. High risk factor D had the highest proportion, accounting for 60.29%. A total of 17 cases of colorectal cancer were detected. From the perspective of cancer staging, 6 cases (35.29%) of early colorectal cancer were lower than 11 cases (64.71%) of advanced malignant tumors. From the perspective of cancer types, 12 cases (70.59%) of rectal cancer were higher than 4 cases (23.53%) of colon cancer and 1 case (5.88%) of lymphoma. There was no statistically significant difference in the composition of cancer types among different stages (P > 0.05). Among 439 high-risk individuals for colorectal cancer, 17 cases (32 high-risk factors) were detected and 422 cases (512 high-risk factors) were not detected. The screening rates of high-risk factors A and B in the undetected colorectal cancer group were 0.95% and 11.85%, respectively, which were lower than those in the colorectal cancer group (17.65% and 35.29%, respectively), and

关 键 词：早期 结直肠癌 伺机性筛查 结果 预防 措施 

分 类 号：R735[医药卫生—肿瘤]