Conventional techniques and emerging nanotechnologies for early detection of cancer metastasis via epithelial-mesenchymal transition monitoring  

作　　者：Zhen Zhang Jing Wang Alain Wuethrich Matt Trau 

机构地区：[1]Centre for Personalized Nanomedicine,Australian Institute for Bioengineering and Nanotechnology(AIBN),The University of Queensland,Brisbane,QLD 4072,Australia [2]Key Laboratory of OptoElectronic Science and Technology for Medicine,Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou 350007,China [3]School of Chemistry and Molecular Biosciences,The University of Queensland,Brisbane,QLD 4072,Australia

出　　处：《National Science Review》2025年第3期437-453,共17页国家科学评论(英文版)

基　　金：supported by the National Natural Science Foundation of China(12074069);the Science Fund Program for Excellent Young Scientists of Fujian(2024J09030);the Joint Funds for the innovation of science and Technology,Fujian Province(2021Y9228);the Guiding Projects of Fujian Province(2023Y0053);the National Health and Medical Research Council(APP1173669);Cancer Australia(2010799);the Australian Research Council(FL220100059).

摘　　要：The epithelial-mesenchymal transition(EMT)is a critical process for cancer to metastasize by promoting invasiveness and dissemination of cancer cells in the body.Understanding and tracking EMT could improve cancer therapy by intervening in metastasis.Current approaches for investigating and detecting the EMT process often utilize traditional molecular biology techniques like immunohistochemistry,mass spectrometry and sequencing.These approaches have provided valuable insights into understanding signaling pathways and identifying biomarkers.Liquid biopsy analysis using advanced nanotechnologies allows the longitudinal tracking of EMT in patients to become feasible.This review article offers a molecular overview of EMT,summarizes current EMT models used in cancer research,and reviews both traditional techniques and emerging nanotechnologies employed in recent EMT studies.Additionally,we discuss the limitations and prospects of applying nanotechnologies in EMT research.By evaluating this rapidly emerging field,we propose strategies to facilitate the clinical translation of nanotechnologies for early detection and monitoring of EMT.

关 键 词：NANOTECHNOLOGIES epithelial-mesenchymal transition cancer metastasis BIOSENSOR liquid biopsy 

分 类 号：R730.2[医药卫生—肿瘤]