多动宁联合盐酸哌甲酯治疗注意力缺陷多动障碍患儿的疗效及安全性  

Efficacy and safety of duodoning combined with methylphenidate hydrochloride in children with attention deficit hyperactivity disorder

作　　者：吴小丽 朱晶波 陈海燕 Wu Xiao-li;Zhu Jing-bo;Chen Hai-yan(Department of Pediatrics,Hai’an People’s Hospital,Hai’an 226600,China)

机构地区：[1]海安市人民医院儿科,海安226600

出　　处：《中国药物应用与监测》2025年第2期319-323,共5页Chinese Journal of Drug Application and Monitoring

摘　　要：目的探讨多动宁胶囊联合盐酸哌甲酯片治疗注意力缺陷多动障碍患儿的临床效果及安全性。方法选取2022年1月至2024年10月海安市人民医院收治的116例注意力缺陷多动障碍患儿,采用随机数字表法分为对照组和观察组,每组58例。研究过程中对照组脱落2例,最终纳入56例;观察组脱落3例,最终纳入55例。对照组口服盐酸哌甲酯片治疗,观察组在对照组的基础上加用多动宁胶囊治疗,疗程均为1个月。观察指标包括临床治疗效果、注意力涣散好转时间、活动过度好转时间、情绪不稳定好转时间、六项中医症候积分、注意缺陷多动障碍评定量表(SNAP-Ⅳ)评分、康纳氏父母症状问卷(PSQ)评分、血清25-羟维生素D3水平及药品不良反应情况。结果观察组治疗总有效率为96.36%(53/55),高于对照组的83.93%(47/56)(χ^(2)=4.806,P<0.05)。观察组注意力涣散好转时间(11.63±1.76)d、活动过度好转时间(10.45±0.99)d、情绪不稳定好转时间(9.56±1.34)d均短于对照组[分别为(15.23±2.12)d、(14.65±1.56)d、(13.65±2.06)d],t值分别为9.741、16.967、12.375,均P<0.001。治疗后,观察组六项中医症候积分、SNAP-Ⅳ评分、PSQ评分均低于对照组(均P<0.05)。治疗后,观察组血清25-羟维生素D3水平[(14.67±1.99)μg·L^(-1)]高于对照组[(11.95±2.03)μg·L^(-1)],t=8.929,P<0.001。两组不良反应发生率分别为3.64%(2/55)和3.57%(2/56),差异无统计学意义(P>0.05)。结论多动宁胶囊联合盐酸哌甲酯片治疗注意力缺陷多动障碍效果显著,能有效改善患儿症状,缩短症状缓解时间,且安全性良好。Objective To investigate the clinical efficacy of duodongning capsule combined with methylphenidate hydrochloride tablets in the treatment of children with attention deficit hyperactivity disorder(ADHD).Methods A total of 116 children with ADHD admitted to Hai’an City People’s Hospital from January 2022 to October 2024 were selected and divided into a control group and an observation group using the random number table method,with 58 in each group.During the study,2 and 3 cases dropped out in the control group and observation,with 56 and 55 cases finally included in the two groups,respectively.The patients in the control group were treated with methylphenidate hydrochloride tablets,while those in the observation group received duodongning capsule based on the regimen in the control group.All the patients in both groups were treated for 1 month.Observation indicators included clinical treatment efficacy,improvement time of attention distraction,hyperactivity,and emotional instability,changes in six traditional Chinese medicine(TCM)symptom scores,SNAP-Ⅳ(Swanson,Nolan and Pelham scale-versionⅣ)scores,PSQ(Conners’Parent Symptom Questionnaire)scores,serum 25-hydroxyvitamin D3 levels,and adverse drug reactions.Results The total effective rate in the observation group was 96.36%(53/55),higher than that in the control group(83.93%,47/56)(χ^(2)=4.806,P=0.028).The improvement times of attention distraction(11.63±1.76)d,hyperactivity(10.45±0.99)d,and emotional instability(9.56±1.34)d in the observation group were shorter than those in the control group((15.23±2.12)d,(14.65±1.56)d,(13.65±2.06)d)(t=9.741,16.967,12.375,all P<0.001).After treatment,the six TCM symptom scores,SNAP-Ⅳscores,and PSQ scores in the observation group were lower than those in the control group(all P<0.05).The serum 25-hydroxyvitamin D3 level in the observation group after treatment(14.67±1.99)μg·L^(-1) was higher than that in the control group(11.95±2.03)μg·L^(-1)(t=8.929,P<0.001).The incidence of adverse reactions in the two g

关 键 词：注意力缺陷多动障碍 多动宁胶囊 盐酸哌甲酯片 治疗效果 药品不良反应 中医症候积分 SNAP-Ⅳ评分 PSQ评分 

分 类 号：R749.94[医药卫生—神经病学与精神病学]