胃苏颗粒联合四联疗法对幽门螺杆菌感染性慢性胃炎患者的效果  

Efficacy of weisu granules combined with quadruple therapy in patients with chronic gastritis associated with helicobacter pylori infection

作　　者：万宁慧 袁林杰 赵波 邓小婧 高琴 Wan Ning-hui;Yuan Lin-jie;Zhao Bo;Deng Xiao-jing;Gao Qin(Department of Gastroenterology,Meishan Hospital of Traditional Chinese Medicine,Meishan 620000,China;Department of Pathology,Meishan Hospital of Traditional Chinese Medicine,Meishan 620000,China;Department of Traditional Chinese Medicine,Chengdu Seventh People’s Hospital,Chengdu 610000,China)

机构地区：[1]眉山市中医医院消化内科,眉山620000 [2]眉山市中医医院病理科,眉山620000 [3]成都市第七人民医院中医科,成都610000

出　　处：《中国药物应用与监测》2025年第2期338-342,共5页Chinese Journal of Drug Application and Monitoring

基　　金：四川省科技计划项目(2021YJ0145)。

摘　　要：目的探究胃苏颗粒联合四联疗法对幽门螺杆菌(HP)感染性慢性胃炎患者的效果。方法选取2020年11月至2023年11月就诊于眉山市中医医院和成都市第七人民医院存在HP感染86例慢性胃炎患者为此次试验对象。按照随机数字表法分为两组,各43例,两组均出现1例脱落,最终各纳入42例。对照组接受根除HP的四联疗法,观察组在此基础上联合胃苏颗粒。治疗14 d后观察两组患者的临床症状改善情况、血清炎症因子水平、E钙黏蛋白水平、胃镜黏膜征象积分、胃功能血清学指标、HP根除率和HP感染复发率。结果在总有效率方面,观察组为92.86%(39/42),高于对照组的73.81%(31/42),差异有统计学意义(χ^(2)=5.486,P=0.019)。治疗后,两组血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平均低于治疗前,且观察组IL-6、TNF-α水平[分别为(133.36±40.27)ng·L^(-1)、(402.93±39.87)pg·mL^(-1)]均低于对照组[分别为(179.61±41.85)ng·L^(-1)、(579.78±40.29)pg·mL^(-1)](t=5.161、20.220,均P<0.05);治疗后,两组E钙黏蛋白水平高于治疗前,且观察组E钙黏蛋白水平高于对照组,差异有统计学意义([189.76±18.32)mg·mL^(-1) vs(158.61±17.45)mg·mL^(-1),t=7.979,P<0.001]。治疗后,两组胃镜黏膜征象总积分低于治疗前,观察胃镜黏膜征象总积分低于对照组[(3.55±1.31)分vs(4.81±1.48)分,t=4.631,P<0.001];治疗后,两组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平均低于治疗前水平,但观察组PGⅠ、PGⅡ[分别为(111.78±18.06)μg·L^(-1)、(9.07±0.98)μg·L^(-1)]均高于对照组[分别为(97.17±12.24)μg·L^(-1)、(8.08±0.96)μg·L^(-1)],差异有统计学意义(t=5.825、4.677,均P<0.05)。观察组HP根除率为88.10%(37/42),对照组为66.67%(28/42),两组比较差异有统计学意义(χ^(2)=5.509,P=0.019);观察组HP感染复发率为4.76%(2/42),对照组为19.05%(8/42),两组比较差异有统计学意义(χ^(2)=4.086,P=0.043)。结论胃苏颗粒联合四联疗法�Objective To evaluate the clinical effectiveness of weisu granules in combination with quadruple therapy for the management of chronic gastritis associated with helicobacter pylori(HP)infection.Methods A total of 86 patients diagnosed with HP infectious chronic gastritis admitted to Meishan Hospital of Traditional Chinese Medicine and Chengdu Seventh People’s Hospital between November 2020 and November 2023 were selected and divided into an observation group and a control group using a random number table method,with 43 in each group.The patients in the control group underwent quadruple therapy for HP eradication,whereas those in the observation group were administered with a combination therapy that included weisu granules in addition.After 14 days of treatment,the clinical symptom improvement,serum inflammatory factor levels,E-cadherin levels,gastroscopy mucosal sign scores,gastric function serological indicators,HP eradication rate and HP infection recurrence rate were determined and compared between the two groups.Results In the observation group,the overall effective rate for alleviating symptoms reached 92.86%(39/42),surpassing the control group's rate of 73.81%(31/42),the disparity observed between these two groups was found to be statistically significant(χ^(2)=5.486,P=0.019).After treatment,the levels of serum interleukin 6(IL-6)and tumor necrosis factorα(TNF-α)in the two groups were lower than those before treatment,and the levels of IL-6 and TNF-αin the observation group((133.36±40.27)ng·L^(-1),(402.93±39.87)pg·mL^(-1))were lower than those in the control((179.61±41.85)ng·L^(-1),(579.78±40.29)pg·mL^(-1))(t=5.161,20.220,both P<0.05).The level of E-cadherin in the two groups was higher than that before treatment,and the level of E-cadherin in the observation group was higher than that in the control, and the difference was statistically significant ((189.76±18.32) mg·mL^(-1) vs (158.61±17.45) mg·mL^(-1), t=7.979, P<0.001). The total score of gastroscopic mucosal signs in the two groups

关 键 词：胃苏颗粒 艾普拉唑 幽门螺杆菌 慢性胃炎 E钙黏蛋白 炎症因子 

分 类 号：R573.3[医药卫生—消化系统]