Antihemorrhagic Effect of the Extract from Blumea megacephala (Randeria) Chang et Tseng on the Uterine Bleeding Model in Early Pregnancy Rats  

作　　者：Xixue NA Shenggao YIN Wentao ZHANG Yuanfeng TAN Wei WEI Xiaoqing NING 

机构地区：[1]Guangxi University of Chinese Medicine,Nanning 530200,China [2]Guangxi Academy of Medical Sciences·the People s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530016,China

出　　处：《Medicinal Plant》2025年第2期40-43,48,共5页药用植物(英文)

基　　金：Supported by the University-level Project of Guangxi University of Chinese Medicine(2021ZD005).

摘　　要：[Objectives]To investigate the effect of extract A from Blumea megacephala(Randeria)Chang et Tseng on the hemostasis of postpartum uterine hemorrhage in early pregnancy rats.[Methods]12 mg/kg of mifepristone and 120μg/kg of misoprostol were used to establish the uterine bleeding model of early pregnancy rats,and the effects of the drugs on the amount of uterine bleeding,the contents of angiotensin II(Ang-II)and prostaglandin E 2(PGE 2)in serum,the four factors of coagulation,platelet adhesion,platelet aggregation and platelet number were investigated.[Results]Extract A can shorten prothrombin time(PT)and activated partial thromboplastin time(APTT)in rats.It can reduce the amount of uterine bleeding in the model,reduce the contents of PGE 2 and Ang-II,reduce APTT and PT,increase the content of fibrinogen FIB,enhance platelet adhesion,enhance platelet aggregation and increase the number of platelets.[Conclusions]Extract A has obvious hemostatic effect on uterine bleeding model of early pregnancy rats.It may play a hemostatic role by affecting vasoconstriction-dilation,coagulation factors in the blood s internal and external coagulation system,platelet adhesion and aggregation,increasing FIB content,increasing platelet number,affecting uterine bleeding,etc.,showing the characteristics of multiple pathways and multiple targets.

关 键 词：Blumea megacephala(Randeria)Chang et Tseng Uterine hemorrhage model of early pregnancy rats HEMOSTASIS Blood vessel BLOOD 

分 类 号：R285.5[医药卫生—中药学]