帕金森病大脑皮层厚度与壳核多巴胺转运体的相关性  

Correlation Between Cortical Thickness and Putamenial Dopamine Transporter in Parkinson's Disease

作　　者：王静[1] 葛璟洁[1] 白侠 吴平[1] 朱毓华 鲁佳荧 林华媚 张慧玮[1] 张政伟[1] 左传涛[1] WANG Jing;GE Jingjie;BAI Xia;WU Ping;ZHU Yuhua;LU Jiaying;LIN Huamei;ZHANG Huiwei;ZHANG Zhengwei;ZUO Chuantao(Department of Nuclear Medicine/PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China;不详)

机构地区：[1]复旦大学附属华山医院核医学/PET中心,上海200235 [2]内蒙古医科大学附属核医学科,内蒙古自治区分子影像学重点实验室,内蒙古呼和浩特010000

出　　处：《中国医学影像学杂志》2025年第3期280-285,共6页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金(82394434,82272039);科技创新2030重大项目(2022ZD0211606);内蒙古自治区科技攻关项目(2021GG0236)。

摘　　要：目的探索不同时期帕金森病(PD)患者大脑皮层厚度特征及其与壳核多巴胺转运体(DAT)的相关性。资料与方法回顾性纳入2016年8月—2020年10月在复旦大学附属华山医院核医学/PET中心行^(11)C-CFTPET和T1MRI扫描的15名健康对照者和30例PD患者。使用SPM12对PET进行图像预处理,获得壳核前部和后部的DAT平均放射性计数,以枕叶作为参考区计算DAT摄取值。使用Freesurfer v7.2软件中的标准处理方法对T1进行组织分割和皮层重建。采用一般线性模型,比较两组间左右脑的皮层厚度差异,并分析差异脑区的皮层厚度与壳核DAT摄取值的相关性。结果与健康对照组相比,PD患者的左侧顶下小叶和额中回下部、右侧额中回下部的皮层明显变薄(P均<0.05)。左侧顶下小叶、右侧额中回下部的皮层厚度与同侧壳核前/后部的DAT摄取值呈显著正相关(r=0.30~0.47,P均<0.05);右侧中央前回与同侧壳核后部的DAT摄取值呈显著正相关且相关性高于对侧(r=0.32,P=0.029)。结论本研究发现PD皮层变薄区域的厚度与壳核DAT水平存在显著正相关,提示了基底神经节皮层环路的重要性并为进一步研究PD神经机制提供依据。Purpose To investigate the cortical thickness features in Parkinson's disease(PD)patients at various stages and their association with dopamine transporter(DAT)levels in the putamen.Materials and Methods We retrospectively enrolled 30 PD patients and 15 healthy subject who underwent^(11)C-CFT PET and T1 MRI scans at the Department of Nuclear Medicine/PET Center of Huashan Hospital from August 2016 to October 2020.DAT average radioactivity in the anterior and posterior putamen was analysis using SPM12 software,with the occipital lobe as the reference region.Cortical segmentation and reconstruction were performed on T1 images using Freesurfer v7.2.The differences in cortical thinning between the groups were compared using a general linear model.Additionally,the relationship between cortical thickness in various brain regions and DAT uptake in the putamen were assessed.Results Compared to healthy subjects,significant cortical thinning was observed in the left inferior parietal lobule and the right and left inferior middle frontal gyrus of PD patients(all P<0.05).There was a significant positive correlation between the cortical thickness of the left inferior parietal lobule and right inferior middle frontal gyrus and DAT uptake in the corresponding anterior/posterior parts of the putamen(r=0.30-0.47,all P<0.05).Furthermore,the DAT uptake in the right precentral gyrus was positively correlated with the ipsilateral posterior putamen,exhibiting a stronger correlation than on the contralateral side(r=0.32,P=0.029).Conclusion The results show that the thickness of the thinning cortex area in the PD patients correlates significantly positively with DAT levels in the putamen,highlighting the importance of the basal ganglia cortical circuit and providing a basis for further research into the neural mechanisms of PD.

关 键 词：帕金森病 正电子发射断层显像 磁共振成像 多巴胺转运体蛋白 脑部皮层厚度 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]