穿刺液降钙素在甲状腺髓样癌中的诊断价值  

Diagnostic value of calcitonin in the aspiration fluid for medullary thyroid carcinoma

作　　者：张丽容[1] 杨梅玉[1] 郑登滋[1] 柯南添 陈则金[1] Zhang Lirong;Yang Meiyu;Zheng Dengzi;Ke Nantian;Chen Zejin(Department of Clinical Laboratory,the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350001,China)

机构地区：[1]福建中医药大学附属第二人民医院检验科,福州350001

出　　处：《实用医技杂志》2025年第3期178-181,I0001,共5页Journal of Practical Medical Techniques

摘　　要：目的探讨穿刺液降钙素在甲状腺髓样癌(MTC)中的诊断价值。方法选取2022年8月至2024年7月在福建中医药大学附属第二人民医院接受甲状腺结节细针穿刺活检(FNAB)的140例患者资料。其中,经病理确诊MTC 30例(MTC组)、甲状腺良性病变55例(良性对照组)、甲状腺乳头状癌52例(PTC对照组)。通过检测各组患者的穿刺液降钙素水平,并分析其与血清降钙素及超声、CT等影像学检查结果的相关性,探讨穿刺液降钙素在MTC诊断中的灵敏度和特异度。结果结果表明,MTC组患者的穿刺液降钙素水平相较于良性对照组和PTC对照组显著偏高(P<0.001),并且穿刺液降钙素水平与血清降钙素水平呈现出明显的正相关关系(r=0.783,P<0.001)。经检测,穿刺液降钙素检测针对MTC的灵敏度为86.7%(26/30),特异度为96.4%(106/110)。结论穿刺液降钙素检测是一种高效、准确的MTC诊断方法,其灵敏度和特异度均高于传统诊断方法,且操作简便、创伤小,有望成为甲状腺髓样癌早期诊断的重要辅助手段。Objective To explore the diagnostic value of calcitonin(CT)in the aspiration fluid for medullary thyroid carcinoma(MTC).Methods The data of 140 patients who underwent fine-needle aspiration biopsy(FNAB)of thyroid nodules in the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine from August 2022 to July 2024 were selected.Among them,30 patients pathologically diagnosed with MTC served as the MTC group.Meanwhile,55 patients with pathologically confirmed thyroid benign lesions during the same period were selected as the benign control group,and 55 patients with papillary thyroid carcinoma(PTC)were chosen as the PTC control group.The calcitonin levels in the aspiration fluid of each group of patients were detected,and the correlations between them and the serum calcitonin levels as well as the results of ultrasound,CT and other imaging examinations were analyzed to explore the sensitivity and specificity of calcitonin in the aspiration fluid for the diagnosis of MTC.Results The results showed that the calcitonin levels in the aspiration fluid of the MTC group were significantly higher than those of the benign control group and the PTC control group(P<0.001),and there was a significant positive correlation between the calcitonin levels in the aspiration fluid and the serum calcitonin levels(r=0.783,P<0.001).Through testing,the sensitivity of the detection of calcitonin in the aspiration fluid for MTC reached 86.7%(26/30),the specificity was 96.4%(106/110).Conclusion This study indicates that the detection of calcitonin in the aspiration fluid is an efficient and accurate diagnostic method for MTC.Its sensitivity and specificity are higher than those of traditional diagnostic methods,and it is simple to operate and causes less trauma.It is expected to become an important auxiliary means for the early diagnosis of medullary thyroid carcinoma.

关 键 词：穿刺检查 降钙素 甲状腺髓样癌 早期诊断 

分 类 号：R736.1[医药卫生—肿瘤]