凝血功能联合超敏C反应蛋白指标在脑梗死早期诊断中的应用价值  

Application value of coagulation function combined with hypersensitive C-reactive protein in early diagnosis of cerebral infarction

作　　者：兰明 Lan Ming(Department of Clinical Laboratory,the First People′s Hospital of Dingnan County,Ganzhou 341900,China)

机构地区：[1]赣州市定南县第一人民医院检验科,赣州341900

出　　处：《实用医技杂志》2025年第3期197-200,共4页Journal of Practical Medical Techniques

摘　　要：目的分析在脑梗死患者的早期诊断中使用凝血功能联合超敏C反应蛋白(hs-CRP)的临床应用价值。方法选取2022年11月至2024年5月定南县第一人民医院收治的80例脑梗死患者作为观察组,并选取同期健康体检者68例作为对照组。2组研究对象均进行活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及纤维蛋白原(FIB)检测,同时测定患者hs-CRP水平,比较对照组与观察组凝血功能与hs-CRP指标水平;根据疾病严重程度分为轻度组、中度组、重度组,比较不同疾病严重程度患者凝血功能与hs-CRP指标水平,分析凝血功能、hs-CRP指标单独及联合诊断的诊断效能。结果观察组患者PT、APTT水平均低于对照组研究对象,而FIB、hs-CPR水平低于对照组;重度组患者PT、APTT水平低于中度组,中度组患者PT、APTT水平低于轻度组;重度组患者FIB、hs-CPR水平高于中度组,中度组患者PT、APTT水平高于轻度组;联合检测对脑梗死早期诊断的灵敏度明显升高,hs-CRP、凝血功能及二者联合检测诊断的曲线下面积(AUC)及(95%CI)分别为0.631(0.540,0.722)、0.855(0.795,0.914)、0.886(0.835,0.937),提示与单项检测相比,联合检测性能较好。结论与健康群体比较,脑梗死患者存在血液高凝状态,且患者机体存在炎症反应,凝血功能指标与hs-CRP的联合检测在脑梗死患者中具有较高的诊断价值。Objective To analyze the clinical application value of coagulation function combined with hypersensitive C-reactive protein(hs-CRP)in early diagnosis of cerebral infarction patients.Methods Eightty patients with cerebral infarction admitted to Dingnan County First People′s Hospital from November 2022 to May 2024 were selected as the observation group,and 68 healthy subjects were selected as the control group during the same period.Activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)were measured in both groups,and hs-CRP levels were measured at the same time.The blood coagulation function and hs-CRP levels were compared between the control group and the observation group.According to the severity of the disease,the patients were divided into mild group,moderate group and severe group.The levels of coagulation function and hs-CRP index were compared in patients with different severity of the disease,and the diagnostic efficacy of coagulation function and hs-CRP index alone and combined diagnosis was analyzed.Results The levels of PT and APTT in observation group were lower than those in control group,while the levels of FIB and hs-CPR were lower than those in control group.PT and APTT levels in severe group were lower than those in moderate group,and PT and APTT levels in moderate group were lower than those in mild group;The levels of FIB and hs-CPR in severe group were higher than those in moderate group,the levels of PT and APTT in moderate group were higher than those in mild group;The sensitivity of combined detection for early diagnosis of cerebral infarction was significantly increased.The AUC(95%CI)of hs-CRP,coagulation function and combined detection were 0.631(0.540,0.722),0.855(0.795,0.914)and 0.886(0.795,0.914),respectively.indicating that the combined detection has better performance than the single detection.Conclusion Compared with the healthy population,cerebral infarction patients have hypercoagulability and inflammation in the body.The combined detection of coagul

关 键 词：脑梗死 早期诊断 凝血功能 超敏C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]