脂肪酸代谢与阿尔茨海默病联系的研究进展  

Research advances on association between fatty acid metabolism and Alzheimer’s disease

作　　者：王妍 徐洁 顾小萍[1] WANG Yan;XU Jie;GU Xiaoping(Department of Anesthesiology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院麻醉科,江苏省南京市210008

出　　处：《实用老年医学》2025年第4期415-419,共5页Practical Geriatrics

基　　金：国家自然科学基金资助项目(82171193);“十四五”江苏省医学重点学科麻醉学项目(ZDXK202232)。

摘　　要：AD是一种与年龄相关的神经退行性疾病,其发病机制一直备受关注。AD的主流学说认为该病主要与淀粉样蛋白(Aβ)和tau蛋白相关。然而,越来越多的研究表明,脂肪酸代谢异常可能贯穿AD的疾病进程,并与其有特殊的病理生理联系。本文从脂肪酸的转运、降解、合成3个方面阐述其与AD的联系和研究新进展,以期为寻找新的潜在靶点提供新思路。Alzheimer’s disease(AD)is an age-associated neurodegenerative disorder,and its pathogenesis has been extensively studied.The mainstream theory shows AD is associated with amyloid-beta(Aβ)and tau protein.However,studies show that abnormal fatty acid metabolism may play a role throughout the progression of AD,with specific physiological and pathological connections.This article summarizes the associations and recent advances on fatty acid transport,degradation and synthesis in relation to AD,aiming to provide new insights for identifying potential therapeutic targets.

关 键 词：阿尔茨海默病 脂肪酸代谢 神经炎症 氧化应激 

分 类 号：R749.16[医药卫生—神经病学与精神病学]