唾液胃蛋白酶测定对咽喉反流性疾病的诊断价值  

Diagnostic value of salivary pepsin measurement in laryngopharyngeal reflux disease

作　　者：冒慧(综述) 姜柳琴(审校)[1] MAO Hui;JIANG Liuqin(Department of Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiang-su,China)

机构地区：[1]南京医科大学第一附属医院消化内科,南京210029

出　　处：《医学研究与战创伤救治》2025年第3期332-336,共5页Journal of Medical Research & Combat Trauma Care

摘　　要：咽喉反流性疾病(LPRD)是指胃内容物反流至食道外引起的咽喉和上呼吸道黏膜的一种炎症性疾病。目前LPRD的诊断方法主要通过症状及调查问卷法,24 h多通道腔内阻抗-pH监测(MII-pH)可提供反流的客观证据是诊断咽喉反流的“金标准”。近年来唾液胃蛋白酶检测在LPRD诊断中的价值备受关注,文章就唾液胃蛋白酶检测在LPRD中的诊断价值进行综述。Laryngopharyngeal reflux disease(LPRD)refers to an inflammatory condition of the mucosa of the pharynx and upper respiratory tract caused by the reflux of gastric contents beyond the esophagus.The current diagnostic approach to LPRD primari-ly involves symptomatology and survey questionnaires.Twenty-four hour multichannel intraluminal impedance pH monitoring(MII-pH)provides objective evidence of reflux,which is considered the"gold standard"for diagnosing laryngopharyngeal reflux.In recent years,the value of salivary pepsin testing in the diagnosis of LPRD has garnered significant attention.This article reviews the diagnostic utility of salivary pepsin measurement in LPRD.

关 键 词：咽喉反流性疾病 唾液胃蛋白酶 诊断价值 

分 类 号：R363[医药卫生—病理学]