双硫仑联合铜在治疗溃疡性结肠炎中的研究进展  

Research progress on disulfiram combined with Cu in the treatment of ulcerative colitis

作　　者：米博文 包秀文 王海强[1] MI Bowen;BAO Xiuwen;WANG Haiqiang(The Second Department of Gastroenterology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院消化二科,黑龙江哈尔滨150040

出　　处：《中国医药导报》2025年第8期77-81,共5页China Medical Herald

摘　　要：溃疡性结肠炎(UC)是一种慢性炎症性肠病,传统治疗方法存在效果有限、副作用大等问题。近年来,双硫仑联合铜(DSF/Cu)在UC治疗中展现出显著的抗炎和免疫调节作用。DSF/Cu通过抑制NF-κB信号通路、阻断TLR信号传导等多种机制,有效减轻肠道炎症反应,促进黏膜修复,并调节肠道菌群平衡。DSF/Cu能显著降低促炎性细胞因子如肿瘤坏死因子-α、白细胞介素-1β和白细胞介素-6水平,同时上调紧密连接蛋白的表达,增强肠屏障功能。此外,DSF/Cu还可通过调控氧化应激和细胞焦亡,进一步减轻肠道损伤。尽管DSF/Cu在UC治疗中表现出良好的临床潜力,但其具体作用机制仍需进一步阐明,且临床应用仍处于初步探索阶段。未来研究应聚焦于开发更高效的药物递送系统,探索DSF/Cu与其他治疗方法的联合应用,以提高治疗效果,并减少潜在副作用。本文简要综述DSF/Cu作为一种新型治疗策略的临床价值,以期为治疗UC提供新的思路和方案。Ulcerative colitis(UC)is a chronic inflammatory bowel disease,traditional treatment methods have problems such as limited effectiveness and significant side effects.In recent years,disulfiram combined with Cu(DSF/Cu)have shown significant anti-inflammatory and immunomodulatory effects in the treatment of UC.DSF/Cu effectively reduces intestinal inflammation,promotes mucosal repair,and regulates intestinal flora balance by inhibiting NF-κB signaling pathway,blocking TLR signaling,and other mechanisms.DSF/Cu can significantly reduce the levels of proinflammatory cytokines such as tumor necrosis factor-α,interleukin-1β,and interleukin-6,while upregulating the expression of tight junction proteins,enhancing intestinal barrier function.In addition,DSF/Cu can further alleviate intestinal damage by regulating oxidative stress and pyroptosis.Although DSF/Cu has shown good clinical potential in the treatment of UC,its specific action mechanism still needs further clarification,and its clinical application is still in the preliminary exploration stage.Future research should focus on developing more efficient drug delivery systems,exploring the combined application of DSF/Cu with other treatment methods to improve treatment efficacy,and reduce potential side effects.This article briefly summarizes clinical value of DSF/Cu as a novel treatment strategy,in order to provide new ideas and plans for the treatment of UC.

关 键 词：双硫仑 铜 溃疡性结肠炎 作用机制 

分 类 号：R574.1[医药卫生—消化系统]