结直肠腺瘤性息肉发病的相关危险因素  

Risk factors associated with colorectal adenomatous polyps

作　　者：田羽佳 杨先照[2] 邢容 王凤磊[4] 张福文[4] 茹淑瑛[4] Tian Yujia;Yang Xianzhao;Xing Rong;Wang Fenglei;Zhang Fuwen;Ru Shuying(Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Department of Infectious Diseases,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Department of Hemodialysis,Tongzhou District,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 101121,China;Department of Gastroenterology,Tongzhou District,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 101121,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学东直门医院感染科,北京100700 [3]北京中医药大学东直门医院通州院区血液透析科,北京101121 [4]北京中医药大学东直门医院通州院区脾胃病科,北京101121

出　　处：《中国医师杂志》2025年第3期411-416,共6页Journal of Chinese Physician

基　　金：北京市通州区科技计划(KJ2022CX061);通州区高层次人才发展支持计划(YHLD2019006)。

摘　　要：目的探究结直肠腺瘤性息肉发病的相关危险因素。方法分析2017年8月—2021年8月在北京中医药大学东直门医院通州院区经结肠镜检查的共计395例患者的临床数据。根据检查结果是否发生腺瘤性息肉分为腺瘤性息肉组(193例)与无息肉组(202例)。采用单因素分析和多因素logistic回归分析,筛选结直肠腺瘤性息肉发病的危险因素。结果单因素分析结果提示:腺瘤性息肉组与无息肉组患者在体重指数(BMI)、性别、年龄、A型血比例、大肠息肉病史、幽门螺杆菌(Hp)感染史、饮酒史、吸烟史、重油饮食比例、口服钙剂史、口服他汀类药物史、口服非甾体类抗炎药史、口服抗生素史、高脂肪饮食(猪肉、牛肉、动物内脏)、高盐饮食、喜腌制食品、喜甜食、喜油腻、情绪良好、焦虑、抑郁、急躁易怒、高血压史、糖尿病史和高脂血症史方面比较,差异均有统计学意义(均P<0.05)。将以上单因素分析中的P<0.05的因素作为自变量,以发病与否作为因变量进行多因素logistic回归分析,结果显示,BMI、年龄、A型血、Hp感染史、饮酒史、吸烟史、口服非甾体类抗炎药史、口服抗生素史、高盐饮食、情绪良好、高血压史是腺瘤性息肉发病的影响因素(均P<0.05)。结论BMI高、年龄大、A型血、Hp感染史、吸烟史、口服非甾体类抗炎药史、口服抗生素史、高盐饮食、高血压史是腺瘤性息肉发病的危险因素,饮酒、情绪良好可以降低结直肠腺瘤性息肉的患病风险,临床可据此为高危患者制订针对性的干预措施,以降低结直肠腺瘤性息肉的发生风险。ObjectiveTo investigate the risk factors of colorectal adenomatous polyps.MethodsThe clinical data of 395 patients who underwent colonoscopy in the Tongzhou branch,Tongzhou District,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine from August 2017 to August 2021 were analyzed.According to the examination results,adenomatous polyps were divided into adenomatous polyps group(193 cases)and non-polyp group(202 cases).The risk factors of colorectal adenomatous polyps were screened by univariate analysis and multivariate logistic regression analysis.ResultsThe results of single factor analysis suggested that:body mass index(BMI),sex,age,proportion of blood type A,history of large intestine polyps,history of Helicobacter pylori(Hp)infection,history of alcohol consumption,history of smoking,proportion of heavy oil diet,history of oral calcium,history of oral statins,history of oral non-steroidal anti-inflammatory drugs,history of oral antibiotics,and high fat diet(pork,beef,and animal organs),high salt diet,love of pickled food,love of sweet food,love of greasy,good mood,anxiety,depression,impatience and irritability,history of hypertension,diabetes and hyperlipidemia were statistically significant in the adenomatous polyp group and the non-polyp group(all P<0.05).Factors with P<0.05 in the above single factor analysis were taken as independent variables,and the incidence of disease was taken as dependent variable for multi-factor logistic regression analysis.The results showed that BMI,age,blood type A,Hp infection history,drinking history,smoking history,oral non-steroidal anti-inflammatory drugs history,oral antibiotics history,high salt diet,good mood,hypertension were the influencing factors for the incidence of adenomatous polyps(all P<0.05).ConclusionsHigh BMI,old age,blood type A,history of Hp infection,smoking history,oral non-steroidal anti-inflammatory drug history,oral antibiotics history,high salt diet and hypertension are risk factors for the development of adenomatous polyps.Drinkin

关 键 词：腺瘤性息肉 结直肠疾病 危险因素 

分 类 号：R735.3[医药卫生—肿瘤]