基于数据挖掘的血管再狭窄动物模型分析  

Vascular restenosis animal model based on data mining

作　　者：谢蓓莉 刘明旺 温伟 闫宇新 郜梦洁 蒋璐莲 金之蝶 赵福海[1,2] XIE Beili;LIU Mingwang;WEN Wei;YAN Yuxin;GAO Mengjie;JIANG Lulian;JIN Zhidie;ZHAO Fuhai(Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China;National Clinical Research Center for Chinese Medicine Cardiology,Beijing 100091;Beijing University of Chinese Medicine,Beijing 100029)

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]国家中医心血管病临床医学中心,北京100091 [3]北京中医药大学,北京100029

出　　处：《中国比较医学杂志》2025年第2期33-44,共12页Chinese Journal of Comparative Medicine

基　　金：中国中医科学院科技创新工程(CI2021A00910);国家自然科学基金(81973674)。

摘　　要：目的对近十年血管再狭窄动物模型的造模方法和评价手段等进行分析统计,为完善血管再狭窄动物模型提供参考。方法检索2013年~2023年中英文主流数据库中的血管再狭窄相关文献,提取纳入文献中的实验动物品系、造模方式、造模周期以及检测方式等数据,通过Excel建立数据库进行汇总分析。结果纳入符合标准的122篇文献中,实验动物品系以大鼠、兔和猪为主,性别以雄性为主,最常用的造模方式为球囊拉伤术,造模周期主要在4~8周之内,检测指标以组织病理学为主,占37.18%,包括常规苏木精-伊红染色、Masson染色、EVG染色等。结论目前猪的血管再狭窄模型翻译转化性较符合预期,但成本较高,难以推广,使用大鼠和兔仍占主流,造模方式以球囊拉伤术为主,不同血管再狭窄动物模型和造模方式各有利弊,应根据实验目的进行选择。血管再狭窄动物模型仍有一定局限性,未来寻求更理想的动物模型势在必然。Objective To analyze the modeling and evaluation method for vascular restenosis animal models in the last 10 years,to provide a reference for improving animal models of vascular restenosis.MethodsLiterature related to vascular restenosis was retrieved from mainstream Chinese and English databases from 2013 to 2023.Data on experimental animal strains,modeling method,modeling cycles,and detection method were extracted from the included literature,and a database was established using Excel for summary analysis.ResultsAmong the 122 identified articles,the main experimental animals were rats,rabbits,and pigs,and most animals were male.The most common modeling method was balloon injury,and the modeling cycle was mainly within 4~8 weeks.The main detection indexes were histopathology,accounting for 37.18%,including routine hematoxylin-eosin,Masson,and Elastica van Gieson(EVG)staining.ConclusionsThe translatability of porcine vascular restenosis models is currently more in line with expectations,but their cost is high and they are unpopular,and rats and rabbits thus remain the main animal models.Balloon injury is the main mode of modeling.Different animal models and modeling method for vascular restenosis have advantages and disadvantages,and the model should be selected according to the experimental purpose.Animal models of vascular restenosis still have some limitations,however,and better animal models are required in the future.

关 键 词：血管再狭窄 动物模型 数据挖掘 球囊拉伤 

分 类 号：R-33[医药卫生]