LncRNA与脑缺血/再灌注损伤相关机制的研究进展  

Research progress in role of LncRNA in mechanisms related to cerebral ischemia/reperfusion injury

作　　者：华志鹏 吕雪[2] 李浩[2] 杨占君[3] 贾建新[3] 杨志甫[1] HUA Zhipeng;LYU Xue;LI Hao;YANG Zhanjun;JIA Jianxin;YANG Zhifu(Department of Neurology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China;Graduate School of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014014;Department of Human Anatomy,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014014)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院神经内科,内蒙古包头014010 [2]内蒙古科技大学包头医学院研究生院,内蒙古包头014014 [3]内蒙古科技大学包头医学院人体解剖学教研室,内蒙古包头014014

出　　处：《中国比较医学杂志》2025年第2期109-115,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81860215);内蒙古自然科学基金(2021MS08010,2018MS08049);内蒙古公立医院科研联合基金科技项目(2024GLLH0499);包头医学院科学研究发展基金项目(BYJJ-2CJH202507)。

摘　　要：脑缺血/再灌注损伤(cerebral ischemia/reperfusion injury,CIRI)是影响急性缺血性脑卒中(acute ischemic stroke,AIS)患者预后的重要病理生理过程,其机制较为复杂,至今尚未完全明确。长链非编码RNA(long non-coding RNA,LncRNA)为非编码RNA(non-coding RNA,ncRNA)中的一类,早期研究多关注于其与肿瘤密切相关。近年来研究发现,LncRNA与CIRI的病理生理过程同样存在密切关系,可通过影响神经系统的氧化应激、细胞自噬及凋亡,炎症反应等机制,参与CIRI的损伤或修复过程,正向或反向调节CIRI的进展,并在所涉及的相关信号通路中扮演重要角色。因此,本文就LncRNA在CIRI中参与调控的相关机制进行综述。Cerebral ischemia/reperfusion injury(CIRI)is a pathophysiological process affecting the prognosis of patients with acute ischemic stroke(AIS).Its mechanism is complex and remains unclear.Long non-coding RNA(LncRNA)are a class of non-coding RNA(ncRNA).Early studies of LncRNA focused on their relationship with tumor-related diseases,but recent studies have found that they are also closely related to the pathological process of CIRI.LncRNA participate in the damage and repair processes of CIRI by affecting oxidative stress,autophagy,and apoptosis of the nervous system,as well as the inflammatory response and other mechanisms.They can regulate the progression of CIRI in a positive or negative way,and they play an important role in the related signaling pathways.This review focuses on the mechanisms by which LncRNA regulate CIRI.

关 键 词：LncRNA 缺血再灌注损伤 脑卒中 

分 类 号：R-33[医药卫生]