表观遗传学在谵妄疾病中的作用和机制研究进展  

Research progress on the role and mechanisms of epigenetics in delirium diseases

作　　者：许欣宜 缪长宏 吴芳颖 肖璐[1] XU Xinyi;MIAO Changhong;WU Fangying;XIAO Lu(Emergency Department,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381;China.2.the Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310000)

机构地区：[1]天津中医药大学第一附属医院急症部,国家中医针灸临床医学研究中心,天津300381 [2]浙江中医药大学第二临床医学院,杭州310000

出　　处：《中国比较医学杂志》2025年第2期116-123,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82405123);天津市教委科研计划项目(2022ZD046);天津中医药大学研究生科研创新项目(YJSKC-20232007)。

摘　　要：谵妄发病率高,易导致患者不良预后,目前发病机制尚不完全明确,临床上主要采取抗精神病药物进行干预,尚无药物能够明确改善谵妄患者远期健康相关生活质量。对非编码核糖核酸、DNA甲基化、组蛋白乙酰化等表观遗传修饰与谵妄发生发展相关研究进行综述,以期为谵妄的早期识别与诊断、治疗及预后提供临床决策,为相关靶向药物的研发提供借鉴。Delirium has a high incidence and is associated with a poor patient prognosis.The pathogenesis of delirium is still unclear.Although antipsychotic drugs are the main intervention in clinical practice,there are currently no drugs that can definitively improve the long-term health-related quality of life in patients with delirium.In this study,we review research on the associations between epigenetic modifications such as non-coding RNAs,DNA methylation,and histone acetylation and the development of delirium,with the aim of providing information to support clinical decisions on the early identification and diagnosis of delirium,as well as its treatment and prognosis and the development of relevant targeted drugs.

关 键 词：谵妄 表观遗传学 非编码核糖核酸 DNA甲基化 组蛋白乙酰化 

分 类 号：R-33[医药卫生]