中医药调控NF-κB信号通路延缓糖尿病肾病进展概述  

Mechanisms by which traditional Chinese medicine modulates the NF-κB signaling pathway to alleviate diabetic kidney disease

作　　者：李鑫[1] 潘志 LI Xin;PAN Zhi(Changchun University of Chinese Medicine,Changchun 130117,China;Jilin Ginseng Science Academy of Changchun University of Chinese Medicine,Changchun 130117)

机构地区：[1]长春中医药大学,长春130117 [2]长春中医药大学吉林省人参科学研究院,长春130117

出　　处：《中国比较医学杂志》2025年第2期131-138,共8页Chinese Journal of Comparative Medicine

基　　金：国家级大学生创新训练计划项目(202310199007);吉林省科技发展计划项目(20230508065RC)。

摘　　要：糖尿病肾病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)的常见并发症,是导致终末期肾病(end-stage renal disease,ESRD)的主要原因。越来越多的证据表明,核因子-κB(nuclear factor kappa-B,NF-κB)信号通路在DKD的发生及发展中起到了关键作用,中医药可通过调控NF-κB信号通路减轻炎症反应,进而延缓DKD进展。就NF-κB信号通路与DKD的关系及中医药干预NF-κB信号通路延缓DKD进展进行综述,旨在为DKD靶向治疗提供新的参考。Diabetic kidney disease(DKD)is a common complication of diabetes mellitus(DM)and a leading cause of end-stage renal disease(ESRD).Increasing evidence indicates that the nuclear factor-kappa B(NF-κB)signaling pathway plays a pivotal role in the onset and progression of DKD.Numerous experimental studies have demonstrated that traditional Chinese medicine can attenuate inflammatory responses by modulating the NF-κB signaling pathway,thereby delaying the progression of DKD.This review summarizes the relationship between the NF-κB signaling pathway and DKD,and discusses advances in research into how traditional Chinese medicine interventions targeting the NF-κB signaling pathway can alleviate DKD,with the aim of providing new references for targeted therapy of DKD.

关 键 词：糖尿病肾病 NF-ΚB信号通路 中医药 

分 类 号：R-33[医药卫生]