迷走神经刺激在注意力神经调控中的作用机制  

Mechanism of vagus nerve stimulation in the neuroregulation of attention

作　　者：支金草 贾雪艳 常庆 徐河 纪维维 王艳[2] ZHI Jincao;JIA Xueyan;CHANG Qing;XU He;JI Weiwei;WANG Yan(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Rehabilitation Centre,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第二医院康复中心,哈尔滨150001

出　　处：《中国比较医学杂志》2025年第2期139-146,共8页Chinese Journal of Comparative Medicine

基　　金：黑龙江省卫生健康委科研课题(20212020010340);黑龙江省中医药管理局资助项目(GY2022-10);孙申田青年人才基金(2021KY-07)。

摘　　要：注意力是机体维持对自身和周围环境刺激的觉醒感知能力,注意力缺陷则会严重影响患者的学习和工作,给家庭和社会带来沉重负担。迷走神经刺激(vagus nerve stimulation,VNS)作为一种新兴的神经调控技术,能实现中枢-周围神经系统的双向交互作用,在治疗神经及精神系统疾病中具有重大潜力,但其尚未被广泛应用于注意力异常的儿童发育障碍/神经退行性疾病的治疗中。本文简要概述了VNS的解剖及生理基础和VNS的应用现状,提出了VNS参与注意力神经调控的潜在机制,旨在为VNS应用于注意力神经调控领域奠定理论基础。Attention refers to the body’s capacity to maintain alert awareness of internal and external stimuli.Attention deficit can impair an individual’s learning capacity and working proficiency,resulting in a heavy burden to the family and society.Vagus nerve stimulation(VNS)is an emerging neuroregulatory technique that can achieve reciprocal interaction between the central and peripheral nervous systems,which has demonstrated great potential for the treatment of neurological and psychiatric diseases;however,it has not been used clinically to treat attention-deficient developmental disorders in children or neurodegenerative diseases in the aged population.We briefly review the anatomical and physiological bases of VNS,and its application status and potential use in treating attention deficit diseases.A potential mechanism by which VNS participates in attention-related nervous regulation is proposed,to lay a theoretical foundation for the application of VNS in the field of attention nervous regulation.

关 键 词：迷走神经刺激 注意力 神经调控 去甲肾上腺素 

分 类 号：R-33[医药卫生]