药物成瘾生物标志物的研究进展  

Research progress on biomarkers of drug addiction

作　　者：黄文欣 张千遥 李小东 田云青 黄俭 张瑞林 HUANG Wenxin;ZHANG Qianyao;LI Xiaodong;TIAN Yunqing;HUANG Jian;ZHANG Ruilin(Key Laboratory of Drug Dependence and Treatment,National Health Commission,School of Forensic Medicine,Kunming Medical University,Kunming 650500,China)

机构地区：[1]国家卫健委毒品依赖和戒治重点实验室,昆明医科大学法医学院,昆明650500

出　　处：《中国比较医学杂志》2025年第2期147-157,共11页Chinese Journal of Comparative Medicine

基　　金：云南省重点研发计划项目(202303AC100021);云南省教育厅科学研究基金项目(2024J0156)。

摘　　要：药物成瘾是一种慢性疾病,不仅会造成个人生理和心理的损害,更重要的是还会对社会造成严重危害。生物标志物是指在健康人群和患者之间存在明显差异的指标,对疾病的诊断和治疗具有重要意义。近年来,药物成瘾患者越来越多,新型毒品的种类和数量也在不断增加,因此对药物成瘾生物标志物的研究受到广泛关注。在多种生物检材中都存在潜在的生物标志物,为此本文综述了毛发、血液、尿液和粪便中可能的生物标志物,为进一步探索药物成瘾的生物特征性标志物提供参考,同时为药物成瘾的临床诊断及治疗提供科学基础。Drug addiction is a chronic disease that causes serious physical and psychological harm to the individual,as well as damage to society.Biomarkers are indicators that differ significantly between healthy people and patients and are important for the diagnosis and treatment of diseases.The increasing incidence of drug addiction in recent years and the wider variety and number of new drugs has led to an increase in the study of biomarkers of drug addiction and their analysis in different biological samples.This paper reviews biomarkers of drug addiction in hair,blood,urine,and feces,to help to explore the biological signatures of drug addiction and facilitate its clinical diagnosis and treatment.

关 键 词：药物成瘾 药物滥用 生物标志物 生物检材 

分 类 号：R-33[医药卫生]