基因编辑技术在实验大动物中的应用  

Application of gene-editing technique in large experimental animals

作　　者：刘超楠 闫丽红 王婧[1] 沈艳华[1] 潘明明 周正宇[1] LIU Chaonan;YAN Lihong;WANG Jing;SHEN Yanhua;PAN Mingming;ZHOU Zhengyu(Laboratory Animal Center of Suzhou Medical College,Soochow University,Suzhou 215000,China;Heilongjiang Agricultural Products and Veterinary Feed Technology Appraisal Station,Harbin 150000)

机构地区：[1]苏州大学苏州医学院实验动物中心,江苏苏州215000 [2]黑龙江省农产品和兽药饲料技术鉴定站,哈尔滨150000

出　　处：《中国比较医学杂志》2025年第2期175-180,共6页Chinese Journal of Comparative Medicine

摘　　要：近年来,随着分子生物学技术的飞速发展,基因编辑作为能够进行基因组修饰的手段,因具有高效性、精确性和灵活性而被用于实验动物模型的建立。本文主要概述了最新的基因编辑技术在实验动物猪、非人灵长类动物以及实验动物犬等动物模型的构建和应用情况,为基因编辑技术在实验大动物的广泛应用和深入研究提供理论参考,从而更好地模拟人类疾病,研究生物医学和人类复杂疾病的潜在发病机制。Recent rapid developments in molecular biological techniques have allowed the use of gene editing,as a means of genome modification,for the establishment of experimental animal models,with high efficiency,accuracy,and flexibility.This article mainly summarizes the construction and application of the latest gene-editing techniques in animal models,including pigs,non-human primates and dogs.It provides a theoretical reference for the application and in-depth study of gene-editing techniques in large experimental animals,which may better simulate human diseases,and for further studies of the potential pathogenesis of biomedical and human complex diseases.

关 键 词：基因编辑 实验动物 模型 

分 类 号：R-33[医药卫生]