银杏二萜内酯葡胺联合倍他司汀治疗缺血性脑卒中伴眩晕的效果  

Efficacy of Ginkgo Diterpene Lactone Meglumine Combined with Betahistine in the Treatment of Ischemic Stroke with Vertigo

作　　者：张秀丽 吴登扣 Zhang Xiuli;Wu Dengkou(Department of Internal Medicine,Yancheng Funing County Hospital of Traditional Chinese Medicine,Yancheng 224400,Jiangsu Province,China)

机构地区：[1]盐城市阜宁县中医院内科,江苏盐城224400

出　　处：《中外医药研究》2025年第8期84-86,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察银杏二萜内酯葡胺联合倍他司汀治疗缺血性脑卒中伴眩晕治疗的效果。方法:以2022年7月—2023年7月盐城市阜宁县中医院收治的100例缺血性脑卒中伴眩晕患者为研究对象,采用随机数字表法分为对照组(n=50,倍他司汀治疗)与观察组(n=50,在对照组基础上联合银杏二萜内酯葡胺治疗)。比较两组临床疗效、氧化应激指标、神经细胞因子水平、不良反应发生情况。结果:观察组治疗总有效率高于对照组(P=0.007);治疗后,两组谷胱甘肽过氧化物酶、超氧化物歧化酶水平升高,丙二醛水平降低,观察组优于对照组(P<0.05);治疗后,两组神经元特异性烯醇化酶水平降低,神经生长因子、脑源性神经营养因子水平升高,观察组优于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏二萜内酯葡胺联合倍他司汀治疗缺血性脑卒中伴眩晕的效果显著,可减轻氧化应激反应,优化神经细胞因子表达。Objective:To observe the efficacy of Ginkgo diterpene lactone meglumine combined with betahistine in the treatment of ischemic stroke with vertigo.Methods:A total of 100 patients with ischemic stroke and vertigo admitted to Yancheng Funing County Hospital of Traditional Chinese Medicine from July 2022 to July 2023 were selected and randomly divided into a control group(n=50,treated with betahistine)and an observation group(n=50,treated with Ginkgo diterpene lactone meglumine combined with betahistine based on the control group).The clinical efficacy,oxidative stress indicators,neurocytokine levels,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P=0.007).After treatment,the levels of glutathione peroxidase and superoxide dismutase increased,while malondialdehyde levels decreased in both groups,with the observation group showing superior outcomes(P<0.05).Post-treatment,neuron-specific enolase levels decreased,while nerve growth factor and brain-derived neurotrophic factor levels increased in both groups,with the observation group demonstrating better results(P<0.05).No statistically significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Ginkgo diterpene lactone meglumine and betahistine demonstrates significant efficacy in treating ischemic stroke with vertigo,alleviating oxidative stress and optimizing neurocytokine expression.

关 键 词：缺血性脑卒中 银杏二萜内酯葡胺 倍他司汀 神经细胞因子 氧化应激反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]