铁蛋白/白蛋白表达与胃癌患者腹腔镜根治术后复发的关系  

Relationship Between Ferritin/Albumin Expression and Recurrence After Laparoscopic Radical Surgery in Patients with Gastric Cancer

作　　者：胡晓明[1] 马沛[1] 董艳萍[1] HU Xiaoming;MA Pei;DONG Yanping(Department of Gastrointestinal Surgery,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院胃肠外科,河南南阳473000

出　　处：《河南医学研究》2025年第7期1287-1290,共4页Henan Medical Research

摘　　要：目的探讨铁蛋白/白蛋白表达水平与胃癌患者腹腔镜根治术后复发的关系。方法选取南阳市第一人民医院2020年2月至2022年2月收治的拟行胃癌根治术的72例胃癌患者进行前瞻性研究,详细统计所有患者一般资料,并检测患者出院时血清铁蛋白、白蛋白水平计算铁蛋白/白蛋白;所有患者随访1 a,依据复发情况分为复发组与未复发组,分析铁蛋白/白蛋白表达水平与胃癌患者腹腔镜根治术后复发的关系。结果72例患者术后均完成1 a随访,其中15例复发(20.83%);复发组肿瘤直径大于未复发组,Ⅲ期患者占比高于未复发组,出院时糖类抗原199(CA199)、CA724、癌胚抗原(CEA)、铁蛋白水平高于未复发组,白蛋白低于未复发组,铁蛋白/白蛋白高于未复发组,差异有统计学意义(P<0.05)。经Cochran-Armitage趋势检验分析显示,肿瘤分期与胃癌患者术后复发呈正相关(r>0,P<0.05);经点二列相关性分析显示,肿瘤直径和出院时铁蛋白、铁蛋白/白蛋白、CEA、CA199、CA724与胃癌患者术后复发呈正相关(r>0,P<0.05),出院时白蛋白水平与胃癌患者术后复发呈负相关(r<0,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示肿瘤直径、肿瘤分期、CEA、CA199、CA724、铁蛋白、白蛋白及铁蛋白/白蛋白对胃癌患者根治术后复发均有一定的预测价值,但铁蛋白/白蛋白预测价值最佳。结论铁蛋白/白蛋白与胃癌患者腹腔镜根治术后复发有关,即铁蛋白/白蛋白升高可增加胃癌患者腹腔镜根治术后复发风险,可作为患者术后复发的早期预测指标。Objective To investigate the relationship between the expression of ferritin/albumin and the recurrence of gastric cancer patients after laparoscopic radical surgery.Methods A prospective study was conducted on 72 patients with gastric cancer who underwent radical gastrectomy for gastric cancer in Nanyang First People’s Hospital from February 2020 to February 2022.The general data of all patients were counted in detail,and the serum ferritin and albumin levels at discharge were detected to calculate ferritin/albumin.All patients were followed up for 1 year.According to the recurrence,they were divided into recurrence group and non-recurrence group.The relationship between ferritin/albumin expression level and recurrence after laparoscopic radical surgery in patients with gastric cancer was analyzed.Results All 72 patients completed a one-year follow-up after surgery,with 15 cases experiencing recurrence(20.83%).The tumor diameter of the recurrence group was larger than that of the non-recurrence group,and the proportion of patients with stageⅢwas higher than that of the non-recurrence group.The levels of carbohydrate antigen 199(CA199),CA724,carcinoembryonic antigen(CEA)and ferritin at discharge were higher than those of the non-recurrence group,albumin was lower than that of the non-recurrence group,and ferritin/albumin was higher than that of the non-recurrence group,with a statistical significant difference(P<0.05).Cochran-Armitage trend test analysis showed that tumor stage was positively correlated with postoperative recurrence of gastric cancer patients(r>0,P<0.05).Correlation analysis showed that tumor diameter,ferritin at discharge,ferritin/albumin,CEA,CA199 and CA724 were positively correlated with postoperative recurrence in patients with gastric cancer(r>0,P<0.05),and albumin level at discharge was negatively correlated with postoperative recurrence of gastric cancer patients(r<0,P<0.05).The receiver operating characteristic(ROC)curve was drawn.The results showed that tumor diameter,tumor stage,CEA

关 键 词：胃癌 根治术 铁蛋白 白蛋白 术后复发 

分 类 号：R735.2[医药卫生—肿瘤]