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作 者:邱吴婧 阮华耀 杨子蔚 唐圆圆 潘悦燊 章倩倩[3] QIU Wujing;RUAN Huayao;YANG Ziwei;TANG Yuanyuan;PAN Yueshen;ZHANG Qianqian(The First School of Clinical Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;School of Public Health,Guangdong Pharmaceutical University,Guangzhou 510006,China;School of Basic Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)
机构地区:[1]广东药科大学第一临床医学院,广东广州510006 [2]广东药科大学公共卫生学院,广东广州510006 [3]广东药科大学基础医学院,广东广州510006
出 处:《广东药科大学学报》2025年第2期165-174,共10页Journal of Guangdong Pharmaceutical University
基 金:大学生创新训练计划项目(S202410573033);广州市科技计划项目(202201010005);广东省教育厅自然科学资金项目(2024KTSCX174);大学生创新创业训练计划项目(20221573056)。
摘 要:皮肤恶性黑色素瘤是一类致死率较高、预后较差的皮肤癌。随着医学技术的发展,皮肤黑色素瘤的治疗手段逐渐多样化和个性化。其临床治疗方案从传统的手术治疗、放疗、化疗,发展到免疫治疗和靶向治疗等多种治疗方法。其中,免疫治疗和靶向治疗的应用提高了皮肤黑色素瘤患者的预后。然而,目前临床用于治疗皮肤黑色素瘤的一线靶向药物仍具有一定的副作用或引起耐药性。因此,皮肤黑色素瘤的靶向药物研究与开发受到广泛关注。本文总结了皮肤恶性黑色素瘤的临床治疗现况,以及近年来对皮肤恶性黑色素瘤具有治疗潜力的潜在靶向药物,以期为皮肤恶性黑色素瘤的临床治疗策略及靶向药物的开发提供科学依据和思路。Cutaneous malignant melanoma is a type of skin cancer with high mortality and poor prognosis.With the development of medical technology,the treatment methods for skin melanoma are gradually becoming more diversified and personalized.The clinical treatment options for patients with cutaneous melanoma has evolved from traditional therapeutic approaches such as surgical operation,radiation therapy and chemotherapy to various therapeutic options such as immunotherapy and target therapy.The outcome of cutaneous melanoma has been improved because of the application of immunotherapy and target therapy.However,the first-line targeted drugs currently used in clinical practice to treat skin melanoma still have certain side effects or cause drug resistance.Therefore,the research and development of targeted drugs for skin melanoma still receive widespread attention.This article summarizes the current clinical treatment status of malignant melanoma of the skin,as well as potential targeted drugs with therapeutic potential for malignant melanoma of the skin in recent years,in order to provide scientific basis and ideas for the clinical treatment strategies and development of targeted drugs for malignant melanoma of the skin.
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