牙龈卟啉单胞菌感染影响宿主DNA损伤修复机制的研究进展  

Research progress on effect of Porphyromonas gingivalis infection on host DNA damage and repair mechanisms

作　　者：马一欣 鲁泽 潘亚萍[1] MA Yixin;LU Ze;PAN Yaping(Department of Periodontics,School and Hospital of Stomatology,China Medical University,Shenyang 110002,China)

机构地区：[1]中国医科大学口腔医学院·附属口腔医院牙周病科,辽宁沈阳110002

出　　处：《口腔生物医学》2025年第2期101-106,共6页Oral Biomedicine

基　　金：国家自然科学基金面上项目(82370975)。

摘　　要：牙龈卟啉单胞菌(P.gingivalis)是牙周感染的关键致病菌,具有激活炎症反应、内化宿主细胞逃避免疫清除、重塑宿主细胞生物学行为等多种致病机制。随着对微生物感染研究的深入,越来越多的证据提示微生物感染与宿主细胞DNA损伤密切相关。本文从P.gingivalis的主要致病性出发,探讨P.gingivalis影响宿主细胞DNA损伤和修复能力的研究进展,为探索P.gingivalis的深层致病机制提供新的思路。Porphyromonas gingivalis(P.gingivalis)is a key pathogen in periodontal infections,with various pathogenic mecha-nisms such as activation of inflammatory responses,internalization of host cells to evade immune clearance,and reshaping of host cell biological behaviors.As research into microbial infections progresses,increasing evidence suggests that microbial infection is closely re-lated to DNA damage of the host cell genome.This article aims to discuss research progress on how P.gingivalis affects DNA damage and repair capabilities of host cells from the perspective of its main pathogenicity,providing new insights for exploring the deeper patho-genic mechanisms of P.gingivalis.

关 键 词：牙龈卟啉单胞菌 DNA损伤 DNA修复 氧化应激 复制应激 

分 类 号：R780.2[医药卫生—口腔医学]