妊娠期糖尿病及子痫前期的微生态变化  

Microbiome changes in gestational diabetes mellitus and preeclampsia

作　　者：叶亭邑 叶畅畅[1] 吴亚菲[1] YE Tingyi;YE Changchang;WU Yafei(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Periodontology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治研究全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周科,四川成都610041

出　　处：《口腔生物医学》2025年第2期117-120,共4页Oral Biomedicine

基　　金：国家自然科学青年基金(81600875)。

摘　　要：妊娠期的孕妇机体会发生体重增加、雌激素和孕酮上升、免疫系统的改变等相应的变化,从而导致人体微生态发生一系列改变。菌群与宿主免疫系统的共同作用会导致疾病的发生发展,可能与妊娠期糖尿病(GDM)、子痫前期(PE)等一系列的妊娠期并发症有关。本文结合近年研究阐述GDM、PE与口腔、肠道、阴道微生态变化的相关性。During pregnancy,the body of pregnant women will undergo corresponding changes,such as weight gain,estrogen and progesterone increase,accompanied by changes in the immune system and other corresponding changes,resulting in a series of changes in the human microecology.The interaction between the flora and the host immune system can lead to the occurrence and development of diseases,which may be related to a series of pregnancy complications such as gestational diabetes mellitus(GDM)and preeclampsia(PE).This review combines recent studies to elaborate the correlation of GDM,PE and microecological changes in oral cavity,intes-tine and vagina.

关 键 词：牙周炎 微生态 妊娠期糖尿病 子痫前期 

分 类 号：R781.42[医药卫生—口腔医学]