血清铁蛋白与三酰甘油葡萄糖指数的交互作用对代谢相关脂肪性肝病的影响  

Serum ferritin and triglyceride-glucose index interaction on metabolic dysfunction-associated fatty liver disease

作　　者：高蕾 周卫红 崔雯霞 潘丰慧 穆丁黄 胡云[1] Gao Lei;Zhou Weihong;Cui Wenxia;Pan Fenghui;Mu Dinghuang;Hu Yun(Department of Geriatrics,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China;Department of Health Management Center,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院老年医学科,南京210008 [2]南京医科大学鼓楼临床医学院健康管理中心,南京210008

出　　处：《中华内分泌代谢杂志》2025年第2期106-110,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的探讨体检人群中血清铁蛋白(serum ferritin,SF)和三酰甘油葡萄糖(triglyceride-glucose,TyG)指数与代谢相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease,MAFLD)的关系,评估SF与TyG指数交互作用对MAFLD的影响。方法选取2022年在南京鼓楼医院健康管理中心的1439名研究对象进行横断面分析,对研究对象进行信息采集、体格检查、实验室检查和腹部影像学检查。比较MAFLD组和非MAFLD组代谢指标及SF、TyG指数的差异。进行logistic回归分析SF和TyG指数与MAFLD的相关性,并进一步分析SF与TyG指数的相加交互作用对MAFLD的影响。结果MAFLD组的SF和TyG指数均显著高于非MAFLD组。校正性别、年龄、高血压病史、糖尿病病史、体重指数、腰围、血红蛋白、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、尿酸后,SF和TyG指数与MAFLD风险显著正相关(OR(95%CI):SF为1.00(1.00~1.00),TyG指数为2.98(2.19~4.06))。SF和TyG指数相加交互作用对MAFLD的影响结果显示,校正相关因素后G4组(SF≥135.4 ng/mL,TyG≥8.52)的MAFLD风险较G1组(SF<135.4 ng/mL,TyG<8.52)显著升高[OR(95%CI):4.43(2.70~7.25)]。结论SF和TyG指数的升高与MAFLD风险增加独立相关,且两者存在显著的协同交互作用。Objective To explore the relationship between serum ferritin(SF),triglyceride-glucose(TyG)index,and metabolic dysfunction-associated fatty liver disease(MAFLD),and to assess their interaction on MAFLD risk in the health checkup population.Methods A cross-sectional analysis was conducted with 1439 participants from the Health Management Centre of Nanjing Drum Tower Hospital in 2022.Data were collected through physical examination,laboratory tests,and abdominal imaging.Differences in metabolic indicators,SF,and TyG index were compared between MAFLD and non-MAFLD groups.Logistic regression analysis was used to assess the associations of SF and TyG index with MAFLD,and their on MAFLD interaction was evaluated.Results Both SF and TyG index were significantly higher in the MAFLD group between than those in the non-MAFLD group(P<0.05).After adjusting for sex,age,history of hypertension,history of diabetes,body mass index,waist circumference,haemoglobin,alanine aminotransferase,aspartate aminotransferase,and uric acid,the SF and TyG index were positively associated with the risk of MAFLD[OR(95%CI),SF:1.00(1.00-1.00);TyG index:2.98(2.19-4.06)].The additive interaction analysis showed that the risk of MAFLD was significantly higher in the G4 group(SF≥135.4 ng/mL,TyG index≥8.52)compared to the G1 group(SF<135.4 ng/mL,TyG index<8.52)[OR 4.43(95%CI 2.70-7.25)].Conclusions Elevated SF and TyG index were independently associated with increased risk of MAFLD,with a significant synergistic interaction between the two.

关 键 词：血清铁蛋白 三酰甘油葡萄糖指数 代谢相关脂肪性肝病 交互作用 

分 类 号：R575[医药卫生—消化系统] R575.5[医药卫生—内科学]