胃癌化疗患者癌因性疲乏现状及其与自我管理效能感和生命质量的相关性  

The status of cancer-caused fatigue in gastric cancer chemotherapy patients and its correlation with self-management efficacy and quality of life

作　　者：白莲 俞丽霞 Bai Lian;Yu Lixia(Clinical School of Medicine,Qinghai University,Xining 810016,China;Department of Medical Oncology,Affiliated Hospital of Qinghai University,Xining 810012,China)

机构地区：[1]青海大学临床医学院,西宁810016 [2]青海大学附属医院肿瘤内科,西宁810012

出　　处：《中国肿瘤临床与康复》2025年第3期191-202,共12页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：青海省卫生健康委一般指导性课题(2020-wjzdx-52)。

摘　　要：目的 探讨胃癌化疗患者化疗期间癌因性疲乏的现状,并分析其与自我管理效能感和生命质量之间的关系。方法 采用便利抽样法,选取2024年8—11月在青海大学附属医院肿瘤内科住院的230例胃癌化疗患者作为研究对象,其中男性179例,女性51例;年龄<45岁21例,45~59岁56例,≥60岁153例。以问卷调查的方式,采用一般资料调查表、癌症疲乏量表(CFS)、癌症自我管理效能感量表(SUPPH)和欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)进行调查。采用Pearson相关性分析探讨癌因性疲乏与自我管理效能感以及生命质量的相关性。采用单因素和多元线性回归分析探讨影响患者癌因性疲乏的因素。结果230例胃癌化疗患者CFS得分为(40.92±5.76)分,其中躯体疲乏得分最高,为(2.98±0.72)分。SUPPH得分为(72.69±14.70)分,其中自我决策得分最高,为(3.01±0.62)分。EORTCQLQ-C30功能领域得分最高的是认知功能,为(82.60±15.83)分;症状领域得分最高的是疲乏症状,为(21.02±15.87)分;单一条目中得分最高的是经济困难,为(42.79±31.18)分;总体健康水平为(61.61±30.69)分。Pearson相关分析结果显示,胃癌化疗患者的CFS得分与SUPPH得分呈负相关(r=-0.72, P<0.001);CFS得分与EORTCQLQC30的功能领域得分呈负相关(r=-0.64,P<0.001),与总体健康状况领域得分呈负相关(r=-0.66,P<0.001),与症状领域得分呈正相关(r=0.37,P<0.001)。多元线性回归分析结果显示,日常运动≥1 h/d、年龄、肿瘤发生部位、总蛋白计数、化疗方案中含有铂类、自我管理效能感和生命质量是胃癌化疗患者癌因性疲乏的独立影响因素(均P<0.05)。结论胃癌化疗患者化疗期间存在癌因性疲乏,临床需加强对患者癌因性疲乏的评估,采取有效措施预防或减轻癌因性疲乏的发生,提高患者生活质量。Objective To explore the status of cancer-related fatigue during chemotherapy in gastric cancer patients and analyze its relationship with self-management efficacy and quality of life.Methods A convenience sampling method was used to select 230 gastric cancer chemotherapy patients hospitalized in the Department of Medical Oncology of the Affiliated Hospital of Qinghai University from August to November 2024,including 179 males and 51 females;21 cases were aged<45 years old,56 cases were aged 45-59 years old,and 153 cases were aged≥60 years old.A questionnaire survey was conducted using a general information survey form,the Cancer Fatigue Scale(CFS),the Cancer Self-Management Efficacy Scale(SUPPH),and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30).Pearson correlation analysis was used to explore the correlation between cancer-related fatigue,self-management efficacy,and quality of life.Univariate and multiple linear regression analyses were conducted to identify factors influencing cancer-related fatigue in patients.Results The CFS score for the 230 gastric cancer chemotherapy patients was(40.92±5.76),with the highest score in physical fatigue at(2.98±0.72).The SUPPH score was(72.69±14.70),with the highest score of self-decision making at(3.01±0.62).The highest score of the EORTC QLQ-C30 functional domain was cognitive functioning at at(82.60±15.83);the highest score in the symptom domain was fatigue symptom at(21.02±15.87),and the highest scorein a single entry was financial difficultiessat(42.79±31.18).The overall health level was(61.61±30.69).Pearson correlation analysis showed that CFS scores were negatively correlated with SUPPH scores in gastric cancer chemotherapy patients(r=-0.72,P<0.001),and the total CFS score was negatively correlated with scores of functional domains of the EORTC QLQ-C30 scale(r=-0.64,P<0.001),negatively correlated with the general health status domain score(r=--0.66,P<0.001),and positively correlated with the sympt

关 键 词：胃肿瘤 癌因性疲乏 生命质量 自我管理效能感 影响因素 

分 类 号：R735.2[医药卫生—肿瘤]