5种血清肿瘤标志物单项检测和联合检测在肺癌辅助诊断中的应用价值分析  

Analysis of application value of single and combined detection of five serum tumor markers in auxiliary diagnosis of lung cancer

作　　者：崔月龙 王利强[1] 王博[1] 杨丽敏[1] CUI Yue-long;WANG Li-qiang;WANC Bo;YANG Li-min(Department of Radiotherapy,Anyang District Hospital of Puyang,Anyang,Henan 455000,China)

机构地区：[1]濮阳市安阳地区医院放疗科,河南安阳455000

出　　处：《医药论坛杂志》2025年第5期500-504,共5页Journal of Medical Forum

摘　　要：目的探讨癌胚抗原(carcinoembryonic antigen,CEA)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、血清细胞角蛋白片段(CYFRA21-1)、组织多肽特异性抗原(tissue polypeptide specific antigen,TPS)、胃泌素释放肽前体(pro-gastrin releasing peptide,Pro-GRP)5种血清肿瘤标志物单项检测和联合检测在肺癌辅助诊断中的应用价值。方法选取2021年6月至2023年6月濮阳市安阳地区医院住院患者、门诊患者和健康体检者共146例,包括肺癌患者50例,肺部良性病症患者48例以及48例健康人员作为正常对照组。对以上病例分别采用电化学发光法和酶联免疫吸附试验的方法实施检测,分析肺癌患者组、肺部良性病症患者组及健康人群组5种血清肿瘤标志物的含量差异,肺癌患者不同病理类型含量和阳性率差异、5项联合检测(CEA、NSE、CYFRA21-1、TPS、Pro-GRP)阳性率与CEA、NSE、CYFRA21-1、TPS、Pro-GRP单项检测阳性率差异。结果肺癌组患者含有的5种血清肿瘤标志物含量大于健康人员和肺部良性病症者组,差异具有统计学意义(P<0.05);肺鳞癌、肺腺癌患者组血清中TPS、CYFRA21-1的含量和阳性率高于肺小细胞癌组,差异具有统计学意义(P<0.05);Pro-GRP与NSE在肺小细胞肺癌患者组血清中含量和阳性率高于肺鳞癌、肺腺癌组,差异具有统计学意义(P<0.05);CEA在肺腺癌患者组的血清含量和阳性率高于肺鳞癌、肺腺癌患者组,差异具有统计学意义(P<0.05);5项联合检测(CEA、NSE、CYFRA21-1、TPS、Pro-GRP)阳性率高于CEA、NSE、CYFRA21-1、TPS、Pro-GRP单项检测,差异具有统计学意义(均P<0.05)。结论肺癌患者5种血清肿瘤标志物(CEA、NSE、CYFRA21-1、TPS、Pro-GRP)含量大于健康人群和肺部良性病症患者;肺鳞癌、肺腺癌患者血液中TPS、CYFRA21-1的含量和阳性率高于肺小细胞癌患者;肺小细胞癌患者血清中Pro-GRP、NSE含量和阳性率高于肺鳞癌、肺腺癌患者;CEA在肺腺癌�Objective To explore the application value of single and combined detection of five serum tumor markers including carcinoembryonic antigen(CEA),neuron specific enolase(NSE),serum cytokeratin fragment(CYFRA21-1),tissue polypeptide specific antigen(TPS),and pro-gastrin releasing peptide(Pro-GRP)in the auxiliary diagnosis of lung cancer.Methods Totally 146 cases of inpatients,outpatient patients,and health examiners were selected from June 2021 to June 2023 in Anyang District Hospital of Puyang,which including 50 lung cancer patients,48 patients with benign lung diseases,and 48 healthy individuals as the normal control group.The above cases were detected using electrochemiluminescence and enzyme-linked immunosorbent assay(ELISA)methods to analyze the differences in the content of five serum tumor markers among lung cancer patients,benign lung disease patients,and healthy population groups.The differences were analyzed in the contents and positive rates of different pathological types of lung cancer patients,the differences were also analyzed in the positive rates of five combined tests(CEA,NSE,CYFRA21-1,TPS,Pro-GRP)and single test of CEA,NSE,CYFRA21-1,TPS,Pro-CRP.Results The contents of five serum tumor markers in the lung cancer group were higher than that in healthy individuals and patients with benign lung diseases,the difference were statistically significant(P<0.05);the contents and positive rates of TPS and CYFRA21-1 in the serum of patients with squamous cell carcinoma and adenocarcinoma of the lung were higher than those of patients with small cell carcinoma of the lung,the difference were statistically significant(P<0.05);the serum levels and positive rates of Pro-CRP and NSE in patients with small cell cancer of the lung were higher than those in patients with squamous cell carcinoma and adenocarcinoma of the lung,the difference were statistically significant(P<0.05);the serum CEA contents and positive rates in adenocarcinoma patients of the lung were higher than those in squamous cell carcinoma and small

关 键 词：肺癌 肿瘤标志物 癌胚抗原 神经元特异性烯醇化酶 CYFRA21-1 组织多肽特异性抗原 胃泌素释放肽前体 

分 类 号：R734.2[医药卫生—肿瘤]