Beyond cancer:The potential application of CD47-based therapy in non-cancer diseases  

作　　者：Wei-Qing Deng Zi-Han Ye Zhenghai Tang Xiao-Lei Zhang Jin-Jian Lu 

机构地区：[1]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China [2]Department of Biomedical Sciences,Faculty of Health Sciences,University of Macao,Macao 999078,China [3]National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation,Guangdong Key Laboratory of Chiral Molecule and Drug Discovery,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China [4]Department of Pharmaceutical Sciences,Faculty of Health Sciences,University of Macao,Macao 999078,China [5]MoE Frontiers Science Center for Precision Oncology,University of Macao,Macao 999078,China

出　　处：《Acta Pharmaceutica Sinica B》2025年第2期757-791,共35页药学学报(英文版)

基　　金：supported by University of Macao(File No.MYRG-GRG2023-00160-ICMS-UMDF,China);the Science and Technology Development Fund,Macao SAR(File No.0015-2022-A1 and 005/2023/SKL,China);as well as the Internal Research Grant of the State Key Laboratory of Quality Research in Chinese Medicine,University of Macao(File No.SKL-QRCM-IRG2023-011,China).

摘　　要：CD47 is an immune checkpoint widely regarded as a‘don't eat me’signal.CD47-based anti-cancer therapy has received considerable attention,with a significant number of clinical trials conducted.While anti-cancer therapies based on CD47 remain a focal point of interest among researchers,it is noteworthy that an increasing number of studies have found that CD47-based therapy ameliorated the pathological status of non-cancer diseases.This review aims to provide an overview of the recent progress in comprehending the role of CD47-based therapy in non-cancer diseases,including diseases of the circulatory system,nervous system,digestive system,and so on.Furthermore,we sought to delineate the promising mechanisms of CD47-based therapy in treating non-cancer diseases.Our findings suggest that CD47-based agents may exert their effect by regulating phagocytosis,regulating T cells,dendritic cells,and neutrophils,and regulating the secretion of cytokines and chemokines.Additionally,we put forward the orientation of further research to bring to light the potential of CD47 and its binding partners as a target in non-cancer diseases.

关 键 词：CD47 Non-cancer disease Application Mechanism PHAGOCYTOSIS Clinical data Preclinical data Future perspective 

分 类 号：R730.5[医药卫生—肿瘤]