Unlocking the healthy human microbiome:Redefining core microbial signatures  

作　　者：Shuting Xi Diya Jiang Qianyi Zhou Hairong Lyu Anita Y.Voigt Xin Zhou Zhemin Zhou Yuan Huang 

机构地区：[1]State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China [2]Key Laboratory of Alkene-carbon Fibres-based Technology&Application for Detection of Major Infectious Diseases,MOE Key Laboratory of Geriatric Diseases and Immunology,Cancer Institute,Suzhou Medical College,Soochow University,Suzhou 215127,China [3]The First Central Clinical College,Tianjin Medical University,Tianjin 300192,China [4]Department of Hematology,Tianjin First Central Hospital,Tianjin 300192,China [5]Department of Dermatology,Duke University School of Medicine,Durham,NC 27710,USA [6]Department of Genetics,Stanford University School of Medicine,Stanford,CA 94305,USA [7]Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine,Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development,Suzhou Medical College,Soochow University,Suzhou 215127,China [8]National Center of Technology Innovation for Biopharmaceuticals,Suzhou Biomedical Industry Innovation Center,Suzhou 215127,China

出　　处：《Acta Pharmaceutica Sinica B》2025年第2期1189-1192,共4页药学学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.82300345,3217003,32370099,and 81901287);the National High-Level Hospital Clinical Research Funding(2023-GSP-QN-23,China);the Provincial-level Talent Program for National Center of Technology Innovation for Biopharmaceuticals(NCTIB2024JS0101,China);the Suzhou Top-Notch Talent Groups(ZXD2022003,China).

摘　　要：Despite the enormous progress made in microbiome research,a comprehensive and universally accepted framework for identifying healthy microbiome biomarkers remains elusive.Defining what constitutes a"healthy"gut microbiome is not an easy task due to its complexity and dynamic nature.Historically,the quest to define a healthy microbiome has centered on identifying biomarkers like microbial diversity and the Firmicutes-to-Bacteroidetes(F/B)ratio.

关 键 词：Gut health GUILDS BIOMARKER Causal inference 

分 类 号：R37[医药卫生—病原生物学]