Harnessing the UDP-G/P2Y_(14)R axis to promote liver regeneration in acute liver failure  

作　　者：Jian-Hong Fang Huichang Bi 

机构地区：[1]NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China

出　　处：《Acta Pharmaceutica Sinica B》2025年第2期1205-1206,共2页药学学报(英文版)

摘　　要：Acute liver failure(ALF)is a life-threatening condition characterized by severe liver dysfunction1.It is primarily caused by bacterial invasion,viral infections(e.g.,hepatitis B or E),or hepatotoxic drugs,notably acetaminophen overdose.Despite its high mortality rate,the liver’s innate regenerative capacity can potentially restore liver function1,2.However,in cases where spontaneous regeneration is insufficient,liver transplantation remains the only curative option in clinic.

关 键 词：Acute liver failure UDP-G P2Y_(14)R Liver regeneration 

分 类 号：R575[医药卫生—消化系统] R575.3[医药卫生—内科学]