喉癌组织miR-145-5p表达变化及在患者顺铂耐药中的作用  

Expression changes of miR-145-5p in laryngeal carcinoma and its role in cisplatin resistance in patients

作　　者：盖霞 盖倩倩 Ge Xia;Ge Qianqian(Hekou District People's Hospital,Dongying City,Shandong Province,257000,China)

机构地区：[1]东营市河口区人民医院,山东东营257000 [2]东营市垦利区垦利街道办事处社区卫生服务中心,山东东营257000

出　　处：《中国医学文摘(耳鼻咽喉科学)》2025年第2期103-105,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的分析喉癌组织miR-145-5p表达变化及在患者顺铂耐药中的作用。方法收集我院耳鼻喉头颈外科107例手术患者的喉癌组织和癌旁组织样本,同时将癌组织样本分为耐药组和未耐药组。通过qRT-PCR技术检测各组样本中miR-145-5p的表达水平,并分析其与顺铂耐药的关系。结果与癌旁组织相比,喉癌组织中miR-145-5p的表达显著降低,组间比较,差异存在统计学意义(P<0.05);耐药组比未耐药组miR-145-5p的表达水平更低,组间比较,差异存在统计学意义(P<0.05)。结论miR-145-5p的下调可能是喉癌化的重要机制之一,也是患者发生顺铂耐药的重要因素。这一研究结果为喉癌的治疗提供了新思路,未来有望通过调控miR-145-5p的表达水平来提升治疗效果,对接下来研究提供基础和依据。Objective To analyze the expression of miR-145-5p in laryngeal carcinoma and its role in cisplatin resistance in patients.Methods Laryngeal cancer and para-cancer tissue samples were collected from 107 patients in the Department of ENT head and neck Surgery in our hospital,and cancer tissue samples were divided into drug resistant group and non-drug resistant group.The expression level of miR-145-5p in samples of each group was detected by qRT-PCR technology,and the relationship between Mir-145-5p and cisplatin resistance was analyzed.Results Compared with adjacent tissues,the expression of miR-145-5p in laryngeal cancer tissues was significantly decreased,and the difference between groups was statistically significant(P<0.05).The expression level of miR-145-5p in drug-resistant group was lower than that in non-drug-resistant group,and the difference between groups was statistically significant(P<0.05).Conclusion The downregulation of miR-145-5p may be one of the important mechanisms of laryngeal carcinoma and an important factor in the development of cisplatin resistance in patients.The results of this study provide a new idea for the treatment of laryngeal cancer,and it is expected to improve the therapeutic effect by regulating the expression level of miR-145-5p in the future,and provide a basis and basis for the next research.

关 键 词：喉癌组织 miR-145-5p表达 顺铂耐药 作用机制 

分 类 号：R739.65[医药卫生—肿瘤]