Halt aging? — functional HSCs lead the way  

作　　者：Rebecca T.Chu Adam B.Schroer Saul A.Villeda 

机构地区：[1]Department of Anatomy,University of California San Francisco,San Francisco,CA,USA [2]Biomedical Sciences Graduate Program,University of California San Francisco,San Francisco,CA,USA [3]Department of Physical Therapy and Rehabilitation Science,San Francisco,CA,USA [4]Bakar Aging Research Institute,San Francisco,CA,USA.

出　　处：《Cell Research》2025年第3期157-158,共2页细胞研究(英文版)

摘　　要：The aged immune system contributes to systemic aging,serving as a driver of morbidity and mortality in the elderly.In a recent Cell Research paper,Wang et al.identified both resilient and dysfunctional subsets of old hematopoietic stem cells(HSCs),of which selective reduction of dysfunctional old HSCs ameliorates aging phenotypes and extends lifespan in mice.Identifying therapeutic targets of systemic aging could begin to address the growing burden of age-related diseases and morbidity in old age.Blood,and the components therein,are posited drivers of aging1,2 and therapeutic targets for rejuvenation.3 Previous work in aging mouse models demonstrated that heterochronic transplantation of bone marrow or peripheral immune cells restore healthspan and extend lifespan3,4—pointing to the potential of targeting hematopoietic stem cells(HSCs)themselves.HSCs are characterized by self-renewal capacity and the ability to give rise to all cells of the blood.

关 键 词：hematopoietic stem cells hscs dysfunctional hscs immune system cell research aging phenotypes functional hscs therapeutic targets systemic aging hematopoietic stem cells 

分 类 号：R73[医药卫生—肿瘤]